Targeted Deletion of HIF-1α Gene in T Cells Prevents their Inhibition in Hypoxic Inflamed Tissues and Improves Septic Mice Survival

BACKGROUND: Sepsis patients may die either from an overwhelming systemic immune response and/or from an immunoparalysis-associated lack of anti-bacterial immune defence. We hypothesized that bacterial superantigen-activated T cells may be prevented from contribution into anti-bacterial response due...

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Detalles Bibliográficos
Autores principales: Thiel, Manfred, Caldwell, Charles C., Kreth, Simone, Kuboki, Satoshi, Chen, P., Smith, Patrick, Ohta, Akio, Lentsch, Alex B., Lukashev, Dmitry, Sitkovsky, Michail V.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1959117/
https://www.ncbi.nlm.nih.gov/pubmed/17786224
http://dx.doi.org/10.1371/journal.pone.0000853

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