Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus

Hepatitis C virus (HCV), a single-stranded positive-sense RNA virus of the Flaviviridae family, infects more than 170 million people worldwide and is the leading cause of liver failure in the United States. A unique feature of HCV is that the viral life cycle depends on cholesterol metabolism in hos...

Descripción completa

Detalles Bibliográficos
Autor principal: Ye, Jin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1959368/
https://www.ncbi.nlm.nih.gov/pubmed/17784784
http://dx.doi.org/10.1371/journal.ppat.0030108
Descripción
Sumario:Hepatitis C virus (HCV), a single-stranded positive-sense RNA virus of the Flaviviridae family, infects more than 170 million people worldwide and is the leading cause of liver failure in the United States. A unique feature of HCV is that the viral life cycle depends on cholesterol metabolism in host cells. This review summarizes the cholesterol metabolic pathways that are required for the replication, secretion, and entry of HCV. The potential application of drugs that alter host cholesterol metabolism in treating HCV infection is also discussed.

Ejemplares similares