Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus

Hepatitis C virus (HCV), a single-stranded positive-sense RNA virus of the Flaviviridae family, infects more than 170 million people worldwide and is the leading cause of liver failure in the United States. A unique feature of HCV is that the viral life cycle depends on cholesterol metabolism in hos...

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Detalles Bibliográficos
Autor principal: Ye, Jin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1959368/
https://www.ncbi.nlm.nih.gov/pubmed/17784784
http://dx.doi.org/10.1371/journal.ppat.0030108
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author Ye, Jin
author_facet Ye, Jin
author_sort Ye, Jin
collection PubMed
description Hepatitis C virus (HCV), a single-stranded positive-sense RNA virus of the Flaviviridae family, infects more than 170 million people worldwide and is the leading cause of liver failure in the United States. A unique feature of HCV is that the viral life cycle depends on cholesterol metabolism in host cells. This review summarizes the cholesterol metabolic pathways that are required for the replication, secretion, and entry of HCV. The potential application of drugs that alter host cholesterol metabolism in treating HCV infection is also discussed.
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spelling pubmed-19593682007-08-30 Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus Ye, Jin PLoS Pathog Review Hepatitis C virus (HCV), a single-stranded positive-sense RNA virus of the Flaviviridae family, infects more than 170 million people worldwide and is the leading cause of liver failure in the United States. A unique feature of HCV is that the viral life cycle depends on cholesterol metabolism in host cells. This review summarizes the cholesterol metabolic pathways that are required for the replication, secretion, and entry of HCV. The potential application of drugs that alter host cholesterol metabolism in treating HCV infection is also discussed. Public Library of Science 2007-08 2007-08-31 /pmc/articles/PMC1959368/ /pubmed/17784784 http://dx.doi.org/10.1371/journal.ppat.0030108 Text en © 2007 Jin Ye. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Review
Ye, Jin
Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus
title Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus
title_full Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus
title_fullStr Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus
title_full_unstemmed Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus
title_short Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus
title_sort reliance of host cholesterol metabolic pathways for the life cycle of hepatitis c virus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1959368/
https://www.ncbi.nlm.nih.gov/pubmed/17784784
http://dx.doi.org/10.1371/journal.ppat.0030108
work_keys_str_mv AT yejin relianceofhostcholesterolmetabolicpathwaysforthelifecycleofhepatitiscvirus

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