In Vitro and In Vivo Neurotoxicity of Prion Protein Oligomers

The mechanisms underlying prion-linked neurodegeneration remain to be elucidated, despite several recent advances in this field. Herein, we show that soluble, low molecular weight oligomers of the full-length prion protein (PrP), which possess characteristics of PrP to PrPsc conversion intermediates...

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Detalles Bibliográficos
Autores principales: Simoneau, Steve, Rezaei, Human, Salès, Nicole, Kaiser-Schulz, Gunnar, Lefebvre-Roque, Maxime, Vidal, Catherine, Fournier, Jean-Guy, Comte, Julien, Wopfner, Franziska, Grosclaude, Jeanne, Schätzl, Hermann, Lasmézas, Corinne Ida
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1959381/
https://www.ncbi.nlm.nih.gov/pubmed/17784787
http://dx.doi.org/10.1371/journal.ppat.0030125

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