Intra-Organ Variation in Age-Related Mutation Accumulation in the Mouse

Using a transgenic mouse model harboring chromosomally integrated lacZ mutational target genes, we previously demonstrated that mutations accumulate with age much more rapidly in the small intestine than in the brain. Here it is shown that in the small intestine point mutations preferentially accumu...

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Detalles Bibliográficos
Autores principales: Busuttil, Rita A., Garcia, Ana Maria, Reddick, Robert L., Dollé, Martijn E. T., Calder, Robert B., Nelson, James F., Vijg, Jan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964533/
https://www.ncbi.nlm.nih.gov/pubmed/17849005
http://dx.doi.org/10.1371/journal.pone.0000876

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