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Secondary Sex Ratio among Women Exposed to Diethylstilbestrol in Utero
BACKGROUND: Diethylstilbestrol (DES), a synthetic estrogen widely prescribed to pregnant women during the mid-1900s, is a potent endocrine disruptor. Previous studies have suggested an association between endocrine-disrupting compounds and secondary sex ratio. METHODS: Data were provided by women pa...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964903/ https://www.ncbi.nlm.nih.gov/pubmed/17805421 http://dx.doi.org/10.1289/ehp.10246 |
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author | Wise, Lauren A. Palmer, Julie R. Hatch, Elizabeth E. Troisi, Rebecca Titus-Ernstoff, Linda Herbst, Arthur L. Kaufman, Raymond Noller, Kenneth L. Hoover, Robert N. |
author_facet | Wise, Lauren A. Palmer, Julie R. Hatch, Elizabeth E. Troisi, Rebecca Titus-Ernstoff, Linda Herbst, Arthur L. Kaufman, Raymond Noller, Kenneth L. Hoover, Robert N. |
author_sort | Wise, Lauren A. |
collection | PubMed |
description | BACKGROUND: Diethylstilbestrol (DES), a synthetic estrogen widely prescribed to pregnant women during the mid-1900s, is a potent endocrine disruptor. Previous studies have suggested an association between endocrine-disrupting compounds and secondary sex ratio. METHODS: Data were provided by women participating in the National Cancer Institute (NCI) DES Combined Cohort Study. We used generalized estimating equations to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the relation of in utero DES exposure to sex ratio (proportion of male births). Models were adjusted for maternal age, child’s birth year, parity, and cohort, and accounted for clustering among women with multiple pregnancies. RESULTS: The OR for having a male birth comparing DES-exposed to unexposed women was 1.05 (95% CI, 0.95–1.17). For exposed women with complete data on cumulative DES dose and timing (33%), those first exposed to DES earlier in gestation and to higher doses had the highest odds of having a male birth. The ORs were 0.91 (95% C, 0.65–1.27) for first exposure at ≥ 13 weeks gestation to < 5 g DES; 0.95 (95% CI, 0.71–1.27) for first exposure at ≥ 13 weeks to ≥ 5 g; 1.16 (95% CI, 0.96–1.41) for first exposure at < 13 weeks to < 5 g; and 1.24 (95% CI, 1.04–1.48) for first exposure at < 13 weeks to ≥ 5 g compared with no exposure. Results did not vary appreciably by maternal age, parity, cohort, or infertility history. CONCLUSIONS: Overall, no association was observed between in utero DES exposure and secondary sex ratio, but a significant increase in the proportion of male births was found among women first exposed to DES earlier in gestation and to a higher cumulative dose. |
format | Text |
id | pubmed-1964903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-19649032007-09-05 Secondary Sex Ratio among Women Exposed to Diethylstilbestrol in Utero Wise, Lauren A. Palmer, Julie R. Hatch, Elizabeth E. Troisi, Rebecca Titus-Ernstoff, Linda Herbst, Arthur L. Kaufman, Raymond Noller, Kenneth L. Hoover, Robert N. Environ Health Perspect Research BACKGROUND: Diethylstilbestrol (DES), a synthetic estrogen widely prescribed to pregnant women during the mid-1900s, is a potent endocrine disruptor. Previous studies have suggested an association between endocrine-disrupting compounds and secondary sex ratio. METHODS: Data were provided by women participating in the National Cancer Institute (NCI) DES Combined Cohort Study. We used generalized estimating equations to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the relation of in utero DES exposure to sex ratio (proportion of male births). Models were adjusted for maternal age, child’s birth year, parity, and cohort, and accounted for clustering among women with multiple pregnancies. RESULTS: The OR for having a male birth comparing DES-exposed to unexposed women was 1.05 (95% CI, 0.95–1.17). For exposed women with complete data on cumulative DES dose and timing (33%), those first exposed to DES earlier in gestation and to higher doses had the highest odds of having a male birth. The ORs were 0.91 (95% C, 0.65–1.27) for first exposure at ≥ 13 weeks gestation to < 5 g DES; 0.95 (95% CI, 0.71–1.27) for first exposure at ≥ 13 weeks to ≥ 5 g; 1.16 (95% CI, 0.96–1.41) for first exposure at < 13 weeks to < 5 g; and 1.24 (95% CI, 1.04–1.48) for first exposure at < 13 weeks to ≥ 5 g compared with no exposure. Results did not vary appreciably by maternal age, parity, cohort, or infertility history. CONCLUSIONS: Overall, no association was observed between in utero DES exposure and secondary sex ratio, but a significant increase in the proportion of male births was found among women first exposed to DES earlier in gestation and to a higher cumulative dose. National Institute of Environmental Health Sciences 2007-09 2007-06-28 /pmc/articles/PMC1964903/ /pubmed/17805421 http://dx.doi.org/10.1289/ehp.10246 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Wise, Lauren A. Palmer, Julie R. Hatch, Elizabeth E. Troisi, Rebecca Titus-Ernstoff, Linda Herbst, Arthur L. Kaufman, Raymond Noller, Kenneth L. Hoover, Robert N. Secondary Sex Ratio among Women Exposed to Diethylstilbestrol in Utero |
title | Secondary Sex Ratio among Women Exposed to Diethylstilbestrol in Utero |
title_full | Secondary Sex Ratio among Women Exposed to Diethylstilbestrol in Utero |
title_fullStr | Secondary Sex Ratio among Women Exposed to Diethylstilbestrol in Utero |
title_full_unstemmed | Secondary Sex Ratio among Women Exposed to Diethylstilbestrol in Utero |
title_short | Secondary Sex Ratio among Women Exposed to Diethylstilbestrol in Utero |
title_sort | secondary sex ratio among women exposed to diethylstilbestrol in utero |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964903/ https://www.ncbi.nlm.nih.gov/pubmed/17805421 http://dx.doi.org/10.1289/ehp.10246 |
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