The intracellular region of Notch ligands: does the tail make the difference?

The cytoplasmic tail of Notch ligands drives endocytosis, mediates association with proteins implicated in the organization of cell-cell junctions and, through regulated intra-membrane proteolysis, is released from the membrane as a signaling fragment. We survey these findings and discuss the role o...

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Detalles Bibliográficos
Autores principales: Pintar, Alessandro, De Biasio, Alfredo, Popovic, Matija, Ivanova, Neli, Pongor, Sándor
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1965462/
https://www.ncbi.nlm.nih.gov/pubmed/17623096
http://dx.doi.org/10.1186/1745-6150-2-19
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author Pintar, Alessandro
De Biasio, Alfredo
Popovic, Matija
Ivanova, Neli
Pongor, Sándor
author_facet Pintar, Alessandro
De Biasio, Alfredo
Popovic, Matija
Ivanova, Neli
Pongor, Sándor
author_sort Pintar, Alessandro
collection PubMed
description The cytoplasmic tail of Notch ligands drives endocytosis, mediates association with proteins implicated in the organization of cell-cell junctions and, through regulated intra-membrane proteolysis, is released from the membrane as a signaling fragment. We survey these findings and discuss the role of Notch ligands intracellular region in bidirectional signaling and possibly in signal modulation in mammals. This article was reviewed by Frank Eisenhaber, L Aravind, and Eugene V. Koonin.
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spelling pubmed-19654622007-09-06 The intracellular region of Notch ligands: does the tail make the difference? Pintar, Alessandro De Biasio, Alfredo Popovic, Matija Ivanova, Neli Pongor, Sándor Biol Direct Review The cytoplasmic tail of Notch ligands drives endocytosis, mediates association with proteins implicated in the organization of cell-cell junctions and, through regulated intra-membrane proteolysis, is released from the membrane as a signaling fragment. We survey these findings and discuss the role of Notch ligands intracellular region in bidirectional signaling and possibly in signal modulation in mammals. This article was reviewed by Frank Eisenhaber, L Aravind, and Eugene V. Koonin. BioMed Central 2007-07-10 /pmc/articles/PMC1965462/ /pubmed/17623096 http://dx.doi.org/10.1186/1745-6150-2-19 Text en Copyright © 2007 Pintar et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Pintar, Alessandro
De Biasio, Alfredo
Popovic, Matija
Ivanova, Neli
Pongor, Sándor
The intracellular region of Notch ligands: does the tail make the difference?
title The intracellular region of Notch ligands: does the tail make the difference?
title_full The intracellular region of Notch ligands: does the tail make the difference?
title_fullStr The intracellular region of Notch ligands: does the tail make the difference?
title_full_unstemmed The intracellular region of Notch ligands: does the tail make the difference?
title_short The intracellular region of Notch ligands: does the tail make the difference?
title_sort intracellular region of notch ligands: does the tail make the difference?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1965462/
https://www.ncbi.nlm.nih.gov/pubmed/17623096
http://dx.doi.org/10.1186/1745-6150-2-19
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