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Cortisol is transported by the multidrug resistance gene product P-glycoprotein.

The physiology of the multidrug transporter P-glycoprotein (Pgp) is still poorly understood. We now show evidence that cell lines with a high expression of Pgp display a reduced accumulation of cortisol and an ATP-dependent outward transport of the hormone. Cortisol efflux from Pgp negative cells do...

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Detalles Bibliográficos
Autores principales: van Kalken, C. K., Broxterman, H. J., Pinedo, H. M., Feller, N., Dekker, H., Lankelma, J., Giaccone, G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968171/
https://www.ncbi.nlm.nih.gov/pubmed/8094292
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author van Kalken, C. K.
Broxterman, H. J.
Pinedo, H. M.
Feller, N.
Dekker, H.
Lankelma, J.
Giaccone, G.
author_facet van Kalken, C. K.
Broxterman, H. J.
Pinedo, H. M.
Feller, N.
Dekker, H.
Lankelma, J.
Giaccone, G.
author_sort van Kalken, C. K.
collection PubMed
description The physiology of the multidrug transporter P-glycoprotein (Pgp) is still poorly understood. We now show evidence that cell lines with a high expression of Pgp display a reduced accumulation of cortisol and an ATP-dependent outward transport of the hormone. Cortisol efflux from Pgp negative cells does not have such an active component. Further we show that the steroid hormones cortisol, testosterone, and progesterone cause an immediate, dose-dependent increase of daunorubicin accumulation in Pgp overexpressing cells. These effects are particularly apparent for the more lipophilic steroids. These results demonstrate that Pgp may function as a transporter for cortisol and suggest a physiological role of the protein in steroid handling by organs such as the adrenal.
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spelling pubmed-19681712009-09-10 Cortisol is transported by the multidrug resistance gene product P-glycoprotein. van Kalken, C. K. Broxterman, H. J. Pinedo, H. M. Feller, N. Dekker, H. Lankelma, J. Giaccone, G. Br J Cancer Research Article The physiology of the multidrug transporter P-glycoprotein (Pgp) is still poorly understood. We now show evidence that cell lines with a high expression of Pgp display a reduced accumulation of cortisol and an ATP-dependent outward transport of the hormone. Cortisol efflux from Pgp negative cells does not have such an active component. Further we show that the steroid hormones cortisol, testosterone, and progesterone cause an immediate, dose-dependent increase of daunorubicin accumulation in Pgp overexpressing cells. These effects are particularly apparent for the more lipophilic steroids. These results demonstrate that Pgp may function as a transporter for cortisol and suggest a physiological role of the protein in steroid handling by organs such as the adrenal. Nature Publishing Group 1993-02 /pmc/articles/PMC1968171/ /pubmed/8094292 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
van Kalken, C. K.
Broxterman, H. J.
Pinedo, H. M.
Feller, N.
Dekker, H.
Lankelma, J.
Giaccone, G.
Cortisol is transported by the multidrug resistance gene product P-glycoprotein.
title Cortisol is transported by the multidrug resistance gene product P-glycoprotein.
title_full Cortisol is transported by the multidrug resistance gene product P-glycoprotein.
title_fullStr Cortisol is transported by the multidrug resistance gene product P-glycoprotein.
title_full_unstemmed Cortisol is transported by the multidrug resistance gene product P-glycoprotein.
title_short Cortisol is transported by the multidrug resistance gene product P-glycoprotein.
title_sort cortisol is transported by the multidrug resistance gene product p-glycoprotein.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968171/
https://www.ncbi.nlm.nih.gov/pubmed/8094292
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