Infrequent chromosome allele loss in fibrolamellar carcinoma.

As yet, there is no reported study of chromosome allele loss in fibrolamellar carcinoma (FLC), a distinct, rare variant of hepatocellular carcinoma (HCC). We searched for evidence of allele loss in FLC using 18 DNA probes for 10 chromosomes and compared the pattern of loss with our series of HCC. Tw...

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Autores principales: Ding, S. F., Delhanty, J. D., Bowles, L., Dooley, J. S., Wood, C. B., Habib, N. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968197/
https://www.ncbi.nlm.nih.gov/pubmed/8094289
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author Ding, S. F.
Delhanty, J. D.
Bowles, L.
Dooley, J. S.
Wood, C. B.
Habib, N. A.
author_facet Ding, S. F.
Delhanty, J. D.
Bowles, L.
Dooley, J. S.
Wood, C. B.
Habib, N. A.
author_sort Ding, S. F.
collection PubMed
description As yet, there is no reported study of chromosome allele loss in fibrolamellar carcinoma (FLC), a distinct, rare variant of hepatocellular carcinoma (HCC). We searched for evidence of allele loss in FLC using 18 DNA probes for 10 chromosomes and compared the pattern of loss with our series of HCC. Two of the probes, lambda MS32 (1q42-43) and cMS621 (5p) showed allele losses in one tumour, while other probes showed no loss. The frequency of allele loss in FLC was much lower than in HCC, which may be associated with their different prognoses. IMAGES:
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spelling pubmed-19681972009-09-10 Infrequent chromosome allele loss in fibrolamellar carcinoma. Ding, S. F. Delhanty, J. D. Bowles, L. Dooley, J. S. Wood, C. B. Habib, N. A. Br J Cancer Research Article As yet, there is no reported study of chromosome allele loss in fibrolamellar carcinoma (FLC), a distinct, rare variant of hepatocellular carcinoma (HCC). We searched for evidence of allele loss in FLC using 18 DNA probes for 10 chromosomes and compared the pattern of loss with our series of HCC. Two of the probes, lambda MS32 (1q42-43) and cMS621 (5p) showed allele losses in one tumour, while other probes showed no loss. The frequency of allele loss in FLC was much lower than in HCC, which may be associated with their different prognoses. IMAGES: Nature Publishing Group 1993-02 /pmc/articles/PMC1968197/ /pubmed/8094289 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ding, S. F.
Delhanty, J. D.
Bowles, L.
Dooley, J. S.
Wood, C. B.
Habib, N. A.
Infrequent chromosome allele loss in fibrolamellar carcinoma.
title Infrequent chromosome allele loss in fibrolamellar carcinoma.
title_full Infrequent chromosome allele loss in fibrolamellar carcinoma.
title_fullStr Infrequent chromosome allele loss in fibrolamellar carcinoma.
title_full_unstemmed Infrequent chromosome allele loss in fibrolamellar carcinoma.
title_short Infrequent chromosome allele loss in fibrolamellar carcinoma.
title_sort infrequent chromosome allele loss in fibrolamellar carcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968197/
https://www.ncbi.nlm.nih.gov/pubmed/8094289
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