Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue.

Epidermal growth factor receptors were measured using a radioligand binding assay in membrane preparations from 67 cancer and 25 non-malignant tissues. The binding characteristics of EGFr were similar in tumour and normal breast membranes. The concentrations were significantly higher in non-malignan...

Descripción completa

Detalles Bibliográficos
Autores principales: Dittadi, R., Donisi, P. M., Brazzale, A., Cappellozza, L., Bruscagnin, G., Gion, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968236/
https://www.ncbi.nlm.nih.gov/pubmed/8427782
_version_ 1782134696931491840
author Dittadi, R.
Donisi, P. M.
Brazzale, A.
Cappellozza, L.
Bruscagnin, G.
Gion, M.
author_facet Dittadi, R.
Donisi, P. M.
Brazzale, A.
Cappellozza, L.
Bruscagnin, G.
Gion, M.
author_sort Dittadi, R.
collection PubMed
description Epidermal growth factor receptors were measured using a radioligand binding assay in membrane preparations from 67 cancer and 25 non-malignant tissues. The binding characteristics of EGFr were similar in tumour and normal breast membranes. The concentrations were significantly higher in non-malignant tissue than in cancer. EGFr concentrations were directly correlated with steroid receptors in non-malignant tissue, whereas in cancer an inverse correlation between EGFr and steroid receptors was found.
format Text
id pubmed-1968236
institution National Center for Biotechnology Information
language English
publishDate 1993
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-19682362009-09-10 Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue. Dittadi, R. Donisi, P. M. Brazzale, A. Cappellozza, L. Bruscagnin, G. Gion, M. Br J Cancer Research Article Epidermal growth factor receptors were measured using a radioligand binding assay in membrane preparations from 67 cancer and 25 non-malignant tissues. The binding characteristics of EGFr were similar in tumour and normal breast membranes. The concentrations were significantly higher in non-malignant tissue than in cancer. EGFr concentrations were directly correlated with steroid receptors in non-malignant tissue, whereas in cancer an inverse correlation between EGFr and steroid receptors was found. Nature Publishing Group 1993-01 /pmc/articles/PMC1968236/ /pubmed/8427782 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Dittadi, R.
Donisi, P. M.
Brazzale, A.
Cappellozza, L.
Bruscagnin, G.
Gion, M.
Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue.
title Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue.
title_full Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue.
title_fullStr Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue.
title_full_unstemmed Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue.
title_short Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue.
title_sort epidermal growth factor receptor in breast cancer. comparison with non malignant breast tissue.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968236/
https://www.ncbi.nlm.nih.gov/pubmed/8427782
work_keys_str_mv AT dittadir epidermalgrowthfactorreceptorinbreastcancercomparisonwithnonmalignantbreasttissue
AT donisipm epidermalgrowthfactorreceptorinbreastcancercomparisonwithnonmalignantbreasttissue
AT brazzalea epidermalgrowthfactorreceptorinbreastcancercomparisonwithnonmalignantbreasttissue
AT cappellozzal epidermalgrowthfactorreceptorinbreastcancercomparisonwithnonmalignantbreasttissue
AT bruscagning epidermalgrowthfactorreceptorinbreastcancercomparisonwithnonmalignantbreasttissue
AT gionm epidermalgrowthfactorreceptorinbreastcancercomparisonwithnonmalignantbreasttissue

Ejemplares similares