Prognostic significance of c-erbB-2 expression in node negative breast cancer.

The prognostic value of c-erbB-2 oncogene expression was studied retrospectively in a consecutive series of 230 node negative breast cancers, followed-up for at least 7 years after primary treatment. The expression of c-erbB-2 oncoprotein was determined on formalin-fixed paraffin-embedded tissue, us...

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Autores principales: Bianchi, S., Paglierani, M., Zampi, G., Cardona, G., Cataliotti, L., Bonardi, R., Ciatto, S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968263/
https://www.ncbi.nlm.nih.gov/pubmed/8094977
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author Bianchi, S.
Paglierani, M.
Zampi, G.
Cardona, G.
Cataliotti, L.
Bonardi, R.
Ciatto, S.
author_facet Bianchi, S.
Paglierani, M.
Zampi, G.
Cardona, G.
Cataliotti, L.
Bonardi, R.
Ciatto, S.
author_sort Bianchi, S.
collection PubMed
description The prognostic value of c-erbB-2 oncogene expression was studied retrospectively in a consecutive series of 230 node negative breast cancers, followed-up for at least 7 years after primary treatment. The expression of c-erbB-2 oncoprotein was determined on formalin-fixed paraffin-embedded tissue, using a monoclonal anti-c-erbB-2 antibody by the avidin-biotin immunoperoxidase method. Positive immunostaining was observed in 20.9% of cases, whereas strong diffuse positivity was recorded only in 8.7% of cases. C-erbB-2 gene product showed no association to T category or nuclear grade. A significant association of c-erbB-2 expression to prognosis was observed only for cases showing a strong diffuse immunostaining, but such an association was no longer statistically significant at multivariate analysis adjusting for other prognostic factors such as T category and nuclear grading. C-erbB-2 expression is of no value to predict the clinical course of node negative patients in the current practice. IMAGES:
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spelling pubmed-19682632009-09-10 Prognostic significance of c-erbB-2 expression in node negative breast cancer. Bianchi, S. Paglierani, M. Zampi, G. Cardona, G. Cataliotti, L. Bonardi, R. Ciatto, S. Br J Cancer Research Article The prognostic value of c-erbB-2 oncogene expression was studied retrospectively in a consecutive series of 230 node negative breast cancers, followed-up for at least 7 years after primary treatment. The expression of c-erbB-2 oncoprotein was determined on formalin-fixed paraffin-embedded tissue, using a monoclonal anti-c-erbB-2 antibody by the avidin-biotin immunoperoxidase method. Positive immunostaining was observed in 20.9% of cases, whereas strong diffuse positivity was recorded only in 8.7% of cases. C-erbB-2 gene product showed no association to T category or nuclear grade. A significant association of c-erbB-2 expression to prognosis was observed only for cases showing a strong diffuse immunostaining, but such an association was no longer statistically significant at multivariate analysis adjusting for other prognostic factors such as T category and nuclear grading. C-erbB-2 expression is of no value to predict the clinical course of node negative patients in the current practice. IMAGES: Nature Publishing Group 1993-03 /pmc/articles/PMC1968263/ /pubmed/8094977 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Bianchi, S.
Paglierani, M.
Zampi, G.
Cardona, G.
Cataliotti, L.
Bonardi, R.
Ciatto, S.
Prognostic significance of c-erbB-2 expression in node negative breast cancer.
title Prognostic significance of c-erbB-2 expression in node negative breast cancer.
title_full Prognostic significance of c-erbB-2 expression in node negative breast cancer.
title_fullStr Prognostic significance of c-erbB-2 expression in node negative breast cancer.
title_full_unstemmed Prognostic significance of c-erbB-2 expression in node negative breast cancer.
title_short Prognostic significance of c-erbB-2 expression in node negative breast cancer.
title_sort prognostic significance of c-erbb-2 expression in node negative breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968263/
https://www.ncbi.nlm.nih.gov/pubmed/8094977
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