Stem cell origins of leukaemia and curability.

It is suggested that most childhood acute lymphoblastic leukaemias and some other paediatric cancers are chemo-curable because they arise in stem cell populations that are functionally transient, chemosensitive and programmed for apoptosis. Most adult acute leukaemias are chemo-incurable at least in...

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Detalles Bibliográficos
Autor principal: Greaves, M. F.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968264/
https://www.ncbi.nlm.nih.gov/pubmed/8439493
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author Greaves, M. F.
author_facet Greaves, M. F.
author_sort Greaves, M. F.
collection PubMed
description It is suggested that most childhood acute lymphoblastic leukaemias and some other paediatric cancers are chemo-curable because they arise in stem cell populations that are functionally transient, chemosensitive and programmed for apoptosis. Most adult acute leukaemias are chemo-incurable at least in part because they originate in relatively drug resistant stem cells with extensive self-renewal capacity. The latter property in turn increases the probability of clones evolving with multi-drug resistance. Particular mutations may superimpose additional adverse features on leukaemic cells.
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spelling pubmed-19682642009-09-10 Stem cell origins of leukaemia and curability. Greaves, M. F. Br J Cancer Research Article It is suggested that most childhood acute lymphoblastic leukaemias and some other paediatric cancers are chemo-curable because they arise in stem cell populations that are functionally transient, chemosensitive and programmed for apoptosis. Most adult acute leukaemias are chemo-incurable at least in part because they originate in relatively drug resistant stem cells with extensive self-renewal capacity. The latter property in turn increases the probability of clones evolving with multi-drug resistance. Particular mutations may superimpose additional adverse features on leukaemic cells. Nature Publishing Group 1993-03 /pmc/articles/PMC1968264/ /pubmed/8439493 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Greaves, M. F.
Stem cell origins of leukaemia and curability.
title Stem cell origins of leukaemia and curability.
title_full Stem cell origins of leukaemia and curability.
title_fullStr Stem cell origins of leukaemia and curability.
title_full_unstemmed Stem cell origins of leukaemia and curability.
title_short Stem cell origins of leukaemia and curability.
title_sort stem cell origins of leukaemia and curability.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968264/
https://www.ncbi.nlm.nih.gov/pubmed/8439493
work_keys_str_mv AT greavesmf stemcelloriginsofleukaemiaandcurability

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