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Cancer mortality and morbidity in employees of the United Kingdom Atomic Energy Authority, 1946-86.

In further analyses of a cohort of 39,718 United Kingdom Atomic Energy Authority employees after 7 more years follow-up, cancer mortality, based on 1,506 deaths in 1946-86, was 20% below the national average. Prostatic cancer mortality showed a statistically significant association with external rad...

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Autores principales: Fraser, P., Carpenter, L., Maconochie, N., Higgins, C., Booth, M., Beral, V.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968277/
https://www.ncbi.nlm.nih.gov/pubmed/8439513
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author Fraser, P.
Carpenter, L.
Maconochie, N.
Higgins, C.
Booth, M.
Beral, V.
author_facet Fraser, P.
Carpenter, L.
Maconochie, N.
Higgins, C.
Booth, M.
Beral, V.
author_sort Fraser, P.
collection PubMed
description In further analyses of a cohort of 39,718 United Kingdom Atomic Energy Authority employees after 7 more years follow-up, cancer mortality, based on 1,506 deaths in 1946-86, was 20% below the national average. Prostatic cancer mortality showed a statistically significant association with external radiation exposure, largely confined to men who were also monitored for internal contamination by radionuclides other than plutonium. Prostatic cancer mortality was highest in radiation workers at Winfrith. In women monitored for radiation exposure, mortality from cancer of the uterus (including the cervix uteri) was increased relative to other employees, and, showed a statistically significant association with external radiation exposure. While there were some other statistically significant results, as would be expected by chance alone when multiple comparisons are made, there were no other cancer sites with consistently exceptional findings. Point estimates for risk associated with increasing exposure to radiation suggest a decrease of four deaths per 10(4) person-years per Sv for leukaemia and an increase of 20 deaths for all cancers except leukaemia, but confidence intervals indicate that a wide range of values are compatible with the data. Cancer morbidity based on 1,699 registrations in 1971-84 was 12% below the national average. Findings from site-specific analyses largely replicated those of the mortality analyses.
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spelling pubmed-19682772009-09-10 Cancer mortality and morbidity in employees of the United Kingdom Atomic Energy Authority, 1946-86. Fraser, P. Carpenter, L. Maconochie, N. Higgins, C. Booth, M. Beral, V. Br J Cancer Research Article In further analyses of a cohort of 39,718 United Kingdom Atomic Energy Authority employees after 7 more years follow-up, cancer mortality, based on 1,506 deaths in 1946-86, was 20% below the national average. Prostatic cancer mortality showed a statistically significant association with external radiation exposure, largely confined to men who were also monitored for internal contamination by radionuclides other than plutonium. Prostatic cancer mortality was highest in radiation workers at Winfrith. In women monitored for radiation exposure, mortality from cancer of the uterus (including the cervix uteri) was increased relative to other employees, and, showed a statistically significant association with external radiation exposure. While there were some other statistically significant results, as would be expected by chance alone when multiple comparisons are made, there were no other cancer sites with consistently exceptional findings. Point estimates for risk associated with increasing exposure to radiation suggest a decrease of four deaths per 10(4) person-years per Sv for leukaemia and an increase of 20 deaths for all cancers except leukaemia, but confidence intervals indicate that a wide range of values are compatible with the data. Cancer morbidity based on 1,699 registrations in 1971-84 was 12% below the national average. Findings from site-specific analyses largely replicated those of the mortality analyses. Nature Publishing Group 1993-03 /pmc/articles/PMC1968277/ /pubmed/8439513 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Fraser, P.
Carpenter, L.
Maconochie, N.
Higgins, C.
Booth, M.
Beral, V.
Cancer mortality and morbidity in employees of the United Kingdom Atomic Energy Authority, 1946-86.
title Cancer mortality and morbidity in employees of the United Kingdom Atomic Energy Authority, 1946-86.
title_full Cancer mortality and morbidity in employees of the United Kingdom Atomic Energy Authority, 1946-86.
title_fullStr Cancer mortality and morbidity in employees of the United Kingdom Atomic Energy Authority, 1946-86.
title_full_unstemmed Cancer mortality and morbidity in employees of the United Kingdom Atomic Energy Authority, 1946-86.
title_short Cancer mortality and morbidity in employees of the United Kingdom Atomic Energy Authority, 1946-86.
title_sort cancer mortality and morbidity in employees of the united kingdom atomic energy authority, 1946-86.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968277/
https://www.ncbi.nlm.nih.gov/pubmed/8439513
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