Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer.

P-glycoprotein (Pgp) and pi-class glutathione S-transferase (GSTP1-1) are thought to be correlated with multiple drug resistance. In immunohistochemical staining, non-seminomatous germ cell tumours, which are more refractory than seminomas to anti-cancer chemotherapy, frequently expressed Pgp and GS...

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Autores principales: Katagiri, A., Tomita, Y., Nishiyama, T., Kimura, M., Sato, S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968284/
https://www.ncbi.nlm.nih.gov/pubmed/8100442
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author Katagiri, A.
Tomita, Y.
Nishiyama, T.
Kimura, M.
Sato, S.
author_facet Katagiri, A.
Tomita, Y.
Nishiyama, T.
Kimura, M.
Sato, S.
author_sort Katagiri, A.
collection PubMed
description P-glycoprotein (Pgp) and pi-class glutathione S-transferase (GSTP1-1) are thought to be correlated with multiple drug resistance. In immunohistochemical staining, non-seminomatous germ cell tumours, which are more refractory than seminomas to anti-cancer chemotherapy, frequently expressed Pgp and GSTP1-1. Western blot analysis demonstrated lower amount of GSTP1-1 in seminoma than in teratoma. These results suggest that Pgp and GSTP1-1 might contribute to drug resistance in testis cancers. IMAGES:
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spelling pubmed-19682842009-09-10 Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer. Katagiri, A. Tomita, Y. Nishiyama, T. Kimura, M. Sato, S. Br J Cancer Research Article P-glycoprotein (Pgp) and pi-class glutathione S-transferase (GSTP1-1) are thought to be correlated with multiple drug resistance. In immunohistochemical staining, non-seminomatous germ cell tumours, which are more refractory than seminomas to anti-cancer chemotherapy, frequently expressed Pgp and GSTP1-1. Western blot analysis demonstrated lower amount of GSTP1-1 in seminoma than in teratoma. These results suggest that Pgp and GSTP1-1 might contribute to drug resistance in testis cancers. IMAGES: Nature Publishing Group 1993-07 /pmc/articles/PMC1968284/ /pubmed/8100442 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Katagiri, A.
Tomita, Y.
Nishiyama, T.
Kimura, M.
Sato, S.
Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer.
title Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer.
title_full Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer.
title_fullStr Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer.
title_full_unstemmed Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer.
title_short Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer.
title_sort immunohistochemical detection of p-glycoprotein and gstp1-1 in testis cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968284/
https://www.ncbi.nlm.nih.gov/pubmed/8100442
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