Response to adjuvant chemotherapy in primary breast cancer: no correlation with expression of glutathione S-transferases.

Of 139 node-positive breast cancer patients treated with adjuvant chemotherapy, the pre-treatment levels of glutathione S-transferase (GST) classes alpha, mu and pi, were determined by immuno-quantification on Western blots in cytosols of the primary tumours. Their expression was studied with respec...

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Detalles Bibliográficos
Autores principales: Peters, W. H., Roelofs, H. M., van Putten, W. L., Jansen, J. B., Klijn, J. G., Foekens, J. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968285/
https://www.ncbi.nlm.nih.gov/pubmed/8318426
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author Peters, W. H.
Roelofs, H. M.
van Putten, W. L.
Jansen, J. B.
Klijn, J. G.
Foekens, J. A.
author_facet Peters, W. H.
Roelofs, H. M.
van Putten, W. L.
Jansen, J. B.
Klijn, J. G.
Foekens, J. A.
author_sort Peters, W. H.
collection PubMed
description Of 139 node-positive breast cancer patients treated with adjuvant chemotherapy, the pre-treatment levels of glutathione S-transferase (GST) classes alpha, mu and pi, were determined by immuno-quantification on Western blots in cytosols of the primary tumours. Their expression was studied with respect to cytosolic oestrogen-receptor, progesterone-receptor and cathepsin D levels, and to the length of disease-free survival. GST class pi was negatively correlated with oestrogen receptor and progesterone receptor, and positively correlated with cathepsin D. There was no correlation between GST isoenzymes and the length of disease-free survival. These data suggest that glutathione S-transferases are not useful as markers to predict the response to adjuvant chemotherapy in human breast cancer. IMAGES:
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spelling pubmed-19682852009-09-10 Response to adjuvant chemotherapy in primary breast cancer: no correlation with expression of glutathione S-transferases. Peters, W. H. Roelofs, H. M. van Putten, W. L. Jansen, J. B. Klijn, J. G. Foekens, J. A. Br J Cancer Research Article Of 139 node-positive breast cancer patients treated with adjuvant chemotherapy, the pre-treatment levels of glutathione S-transferase (GST) classes alpha, mu and pi, were determined by immuno-quantification on Western blots in cytosols of the primary tumours. Their expression was studied with respect to cytosolic oestrogen-receptor, progesterone-receptor and cathepsin D levels, and to the length of disease-free survival. GST class pi was negatively correlated with oestrogen receptor and progesterone receptor, and positively correlated with cathepsin D. There was no correlation between GST isoenzymes and the length of disease-free survival. These data suggest that glutathione S-transferases are not useful as markers to predict the response to adjuvant chemotherapy in human breast cancer. IMAGES: Nature Publishing Group 1993-07 /pmc/articles/PMC1968285/ /pubmed/8318426 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Peters, W. H.
Roelofs, H. M.
van Putten, W. L.
Jansen, J. B.
Klijn, J. G.
Foekens, J. A.
Response to adjuvant chemotherapy in primary breast cancer: no correlation with expression of glutathione S-transferases.
title Response to adjuvant chemotherapy in primary breast cancer: no correlation with expression of glutathione S-transferases.
title_full Response to adjuvant chemotherapy in primary breast cancer: no correlation with expression of glutathione S-transferases.
title_fullStr Response to adjuvant chemotherapy in primary breast cancer: no correlation with expression of glutathione S-transferases.
title_full_unstemmed Response to adjuvant chemotherapy in primary breast cancer: no correlation with expression of glutathione S-transferases.
title_short Response to adjuvant chemotherapy in primary breast cancer: no correlation with expression of glutathione S-transferases.
title_sort response to adjuvant chemotherapy in primary breast cancer: no correlation with expression of glutathione s-transferases.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968285/
https://www.ncbi.nlm.nih.gov/pubmed/8318426
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