Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer.

Thirty-four primary, untreated sporadic breast cancers were examined for loss of heterozygosity (LOH) at tumour suppressor loci involved in colorectal cancer: APC/MCC at 5q21 and DCC at 18q21. LOH was identified in 28% informative patients at 5q21 and 31% at 18q21. LOH at 5q21 and 18q21 was compared...

Descripción completa

Detalles Bibliográficos
Autores principales: Thompson, A. M., Morris, R. G., Wallace, M., Wyllie, A. H., Steel, C. M., Carter, D. C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968317/
https://www.ncbi.nlm.nih.gov/pubmed/8318422
_version_ 1782134713709756416
author Thompson, A. M.
Morris, R. G.
Wallace, M.
Wyllie, A. H.
Steel, C. M.
Carter, D. C.
author_facet Thompson, A. M.
Morris, R. G.
Wallace, M.
Wyllie, A. H.
Steel, C. M.
Carter, D. C.
author_sort Thompson, A. M.
collection PubMed
description Thirty-four primary, untreated sporadic breast cancers were examined for loss of heterozygosity (LOH) at tumour suppressor loci involved in colorectal cancer: APC/MCC at 5q21 and DCC at 18q21. LOH was identified in 28% informative patients at 5q21 and 31% at 18q21. LOH at 5q21 and 18q21 was compared with allele loss at 17p13 and concurrent LOH at two or more of the loci was noted in 24% of tumours. Expression of a 12 kb DCC mRNA was demonstrated in 14/34 (42%) of the cancers and in all five tumours with LOH at the DCC locus there was an additional 11 kb DCC mRNA. Abnormalities of three loci involved in colorectal cancer (5q21, 17p13 and 18q21) therefore also occur in sporadic breast cancer. The accumulation of such genetic abnormalities may confer a growth advantage important in the development of breast cancer. IMAGES:
format Text
id pubmed-1968317
institution National Center for Biotechnology Information
language English
publishDate 1993
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-19683172009-09-10 Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer. Thompson, A. M. Morris, R. G. Wallace, M. Wyllie, A. H. Steel, C. M. Carter, D. C. Br J Cancer Research Article Thirty-four primary, untreated sporadic breast cancers were examined for loss of heterozygosity (LOH) at tumour suppressor loci involved in colorectal cancer: APC/MCC at 5q21 and DCC at 18q21. LOH was identified in 28% informative patients at 5q21 and 31% at 18q21. LOH at 5q21 and 18q21 was compared with allele loss at 17p13 and concurrent LOH at two or more of the loci was noted in 24% of tumours. Expression of a 12 kb DCC mRNA was demonstrated in 14/34 (42%) of the cancers and in all five tumours with LOH at the DCC locus there was an additional 11 kb DCC mRNA. Abnormalities of three loci involved in colorectal cancer (5q21, 17p13 and 18q21) therefore also occur in sporadic breast cancer. The accumulation of such genetic abnormalities may confer a growth advantage important in the development of breast cancer. IMAGES: Nature Publishing Group 1993-07 /pmc/articles/PMC1968317/ /pubmed/8318422 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Thompson, A. M.
Morris, R. G.
Wallace, M.
Wyllie, A. H.
Steel, C. M.
Carter, D. C.
Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer.
title Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer.
title_full Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer.
title_fullStr Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer.
title_full_unstemmed Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer.
title_short Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer.
title_sort allele loss from 5q21 (apc/mcc) and 18q21 (dcc) and dcc mrna expression in breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968317/
https://www.ncbi.nlm.nih.gov/pubmed/8318422
work_keys_str_mv AT thompsonam allelelossfrom5q21apcmccand18q21dccanddccmrnaexpressioninbreastcancer
AT morrisrg allelelossfrom5q21apcmccand18q21dccanddccmrnaexpressioninbreastcancer
AT wallacem allelelossfrom5q21apcmccand18q21dccanddccmrnaexpressioninbreastcancer
AT wyllieah allelelossfrom5q21apcmccand18q21dccanddccmrnaexpressioninbreastcancer
AT steelcm allelelossfrom5q21apcmccand18q21dccanddccmrnaexpressioninbreastcancer
AT carterdc allelelossfrom5q21apcmccand18q21dccanddccmrnaexpressioninbreastcancer

Ejemplares similares