The identification of high and low risk groups for colorectal cancer using rectal mucosal crypt cell production rate (CCPR).

Rectal mucosal proliferation was measured in 116 individuals using the metaphase arrest technique crypt cell production rate (CCPR). CCPR was found to be significantly elevated in individuals with adenomas (n = 42, CCPR = 13 cc c-1h-1, range 7-25 Cl 10-15) compared with normals (n = 21, CCPR = 10 cc...

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Autores principales: Rooney, P. S., Clarke, P. A., Gifford, K. A., Hardcastle, J. D., Armitage, N. C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968319/
https://www.ncbi.nlm.nih.gov/pubmed/8318409
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author Rooney, P. S.
Clarke, P. A.
Gifford, K. A.
Hardcastle, J. D.
Armitage, N. C.
author_facet Rooney, P. S.
Clarke, P. A.
Gifford, K. A.
Hardcastle, J. D.
Armitage, N. C.
author_sort Rooney, P. S.
collection PubMed
description Rectal mucosal proliferation was measured in 116 individuals using the metaphase arrest technique crypt cell production rate (CCPR). CCPR was found to be significantly elevated in individuals with adenomas (n = 42, CCPR = 13 cc c-1h-1, range 7-25 Cl 10-15) compared with normals (n = 21, CCPR = 10 cc c-1h-1 range 5-24 Cl 7-11, Mann-Whitney P = 0.001 z = 3.2). Mucosal proliferation was increased among individuals who were undergoing adenoma follow up but in whom no further adenomas were found (n = 37 CCPR = 12 range 5-26 cc c-1h-1 Cl 10-14) compared to controls (Mann-Whitney P = 0.01 z = 2.4) Proliferation in vegetarians i.e. low risk (n = 16) was similar to controls. Measurement of proliferative indices in rectal mucosa by the stathmokinetic technique CCPR can discriminate between high and low risk groups for colorectal cancer.
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spelling pubmed-19683192009-09-10 The identification of high and low risk groups for colorectal cancer using rectal mucosal crypt cell production rate (CCPR). Rooney, P. S. Clarke, P. A. Gifford, K. A. Hardcastle, J. D. Armitage, N. C. Br J Cancer Research Article Rectal mucosal proliferation was measured in 116 individuals using the metaphase arrest technique crypt cell production rate (CCPR). CCPR was found to be significantly elevated in individuals with adenomas (n = 42, CCPR = 13 cc c-1h-1, range 7-25 Cl 10-15) compared with normals (n = 21, CCPR = 10 cc c-1h-1 range 5-24 Cl 7-11, Mann-Whitney P = 0.001 z = 3.2). Mucosal proliferation was increased among individuals who were undergoing adenoma follow up but in whom no further adenomas were found (n = 37 CCPR = 12 range 5-26 cc c-1h-1 Cl 10-14) compared to controls (Mann-Whitney P = 0.01 z = 2.4) Proliferation in vegetarians i.e. low risk (n = 16) was similar to controls. Measurement of proliferative indices in rectal mucosa by the stathmokinetic technique CCPR can discriminate between high and low risk groups for colorectal cancer. Nature Publishing Group 1993-07 /pmc/articles/PMC1968319/ /pubmed/8318409 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Rooney, P. S.
Clarke, P. A.
Gifford, K. A.
Hardcastle, J. D.
Armitage, N. C.
The identification of high and low risk groups for colorectal cancer using rectal mucosal crypt cell production rate (CCPR).
title The identification of high and low risk groups for colorectal cancer using rectal mucosal crypt cell production rate (CCPR).
title_full The identification of high and low risk groups for colorectal cancer using rectal mucosal crypt cell production rate (CCPR).
title_fullStr The identification of high and low risk groups for colorectal cancer using rectal mucosal crypt cell production rate (CCPR).
title_full_unstemmed The identification of high and low risk groups for colorectal cancer using rectal mucosal crypt cell production rate (CCPR).
title_short The identification of high and low risk groups for colorectal cancer using rectal mucosal crypt cell production rate (CCPR).
title_sort identification of high and low risk groups for colorectal cancer using rectal mucosal crypt cell production rate (ccpr).
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968319/
https://www.ncbi.nlm.nih.gov/pubmed/8318409
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