TGF-beta expression in the human colon: differential immunostaining along crypt epithelium.

Samples of colorectal carcinoma, adenoma and normal colorectal mucosa were examined for the expression of TGF-beta by immunohistochemistry. Immunoreactivity for TGF-beta was present in 52 out of a total of 58 samples of normal mucosa examined. In adenomas and carcinomas TGF-beta expression was obser...

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Autores principales: Avery, A., Paraskeva, C., Hall, P., Flanders, K. C., Sporn, M., Moorghen, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968322/
https://www.ncbi.nlm.nih.gov/pubmed/8318404
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author Avery, A.
Paraskeva, C.
Hall, P.
Flanders, K. C.
Sporn, M.
Moorghen, M.
author_facet Avery, A.
Paraskeva, C.
Hall, P.
Flanders, K. C.
Sporn, M.
Moorghen, M.
author_sort Avery, A.
collection PubMed
description Samples of colorectal carcinoma, adenoma and normal colorectal mucosa were examined for the expression of TGF-beta by immunohistochemistry. Immunoreactivity for TGF-beta was present in 52 out of a total of 58 samples of normal mucosa examined. In adenomas and carcinomas TGF-beta expression was observed in eight out of ten and 46 out of 48 samples respectively and was largely restricted to epithelial cells. In normal mucosa differential expression of TGF-beta was present within epithelial cells, those in the upper parts of the crypts showing enhanced immunoreactivity compared to cells in the proliferative compartment. This pattern of differential staining is consistent with TGF-beta having an important role in the control of growth and differentiation in colonic mucosa. IMAGES:
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spelling pubmed-19683222009-09-10 TGF-beta expression in the human colon: differential immunostaining along crypt epithelium. Avery, A. Paraskeva, C. Hall, P. Flanders, K. C. Sporn, M. Moorghen, M. Br J Cancer Research Article Samples of colorectal carcinoma, adenoma and normal colorectal mucosa were examined for the expression of TGF-beta by immunohistochemistry. Immunoreactivity for TGF-beta was present in 52 out of a total of 58 samples of normal mucosa examined. In adenomas and carcinomas TGF-beta expression was observed in eight out of ten and 46 out of 48 samples respectively and was largely restricted to epithelial cells. In normal mucosa differential expression of TGF-beta was present within epithelial cells, those in the upper parts of the crypts showing enhanced immunoreactivity compared to cells in the proliferative compartment. This pattern of differential staining is consistent with TGF-beta having an important role in the control of growth and differentiation in colonic mucosa. IMAGES: Nature Publishing Group 1993-07 /pmc/articles/PMC1968322/ /pubmed/8318404 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Avery, A.
Paraskeva, C.
Hall, P.
Flanders, K. C.
Sporn, M.
Moorghen, M.
TGF-beta expression in the human colon: differential immunostaining along crypt epithelium.
title TGF-beta expression in the human colon: differential immunostaining along crypt epithelium.
title_full TGF-beta expression in the human colon: differential immunostaining along crypt epithelium.
title_fullStr TGF-beta expression in the human colon: differential immunostaining along crypt epithelium.
title_full_unstemmed TGF-beta expression in the human colon: differential immunostaining along crypt epithelium.
title_short TGF-beta expression in the human colon: differential immunostaining along crypt epithelium.
title_sort tgf-beta expression in the human colon: differential immunostaining along crypt epithelium.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968322/
https://www.ncbi.nlm.nih.gov/pubmed/8318404
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