Prognostic significance of cathepsin-D in patients with breast cancer.

The expression of the protease cathepsin-D has been evaluated using an immunohistochemical technique with a polyclonal antibody in paraffin-embedded tissue from 359 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and twenty seven patients (35%) have strongl...

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Autores principales: Winstanley, J. H., Leinster, S. J., Cooke, T. G., Westley, B. R., Platt-Higgins, A. M., Rudland, P. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968341/
https://www.ncbi.nlm.nih.gov/pubmed/8471433
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author Winstanley, J. H.
Leinster, S. J.
Cooke, T. G.
Westley, B. R.
Platt-Higgins, A. M.
Rudland, P. S.
author_facet Winstanley, J. H.
Leinster, S. J.
Cooke, T. G.
Westley, B. R.
Platt-Higgins, A. M.
Rudland, P. S.
author_sort Winstanley, J. H.
collection PubMed
description The expression of the protease cathepsin-D has been evaluated using an immunohistochemical technique with a polyclonal antibody in paraffin-embedded tissue from 359 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and twenty seven patients (35%) have strongly positive, granular staining, 138 (38%) are intermediately stained in the cytoplasm, and in 94 (26%) no staining is observed. There is a strong positive association between expression of cathepsin-D and the presence of tumour in axillary lymph nodes (P < 0.006). Expression of the protease is associated with significantly poorer survival of patients in univariate analysis (P = 0.025); however, this is not independent of other tumour variables. IMAGES:
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spelling pubmed-19683412009-09-10 Prognostic significance of cathepsin-D in patients with breast cancer. Winstanley, J. H. Leinster, S. J. Cooke, T. G. Westley, B. R. Platt-Higgins, A. M. Rudland, P. S. Br J Cancer Research Article The expression of the protease cathepsin-D has been evaluated using an immunohistochemical technique with a polyclonal antibody in paraffin-embedded tissue from 359 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and twenty seven patients (35%) have strongly positive, granular staining, 138 (38%) are intermediately stained in the cytoplasm, and in 94 (26%) no staining is observed. There is a strong positive association between expression of cathepsin-D and the presence of tumour in axillary lymph nodes (P < 0.006). Expression of the protease is associated with significantly poorer survival of patients in univariate analysis (P = 0.025); however, this is not independent of other tumour variables. IMAGES: Nature Publishing Group 1993-04 /pmc/articles/PMC1968341/ /pubmed/8471433 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Winstanley, J. H.
Leinster, S. J.
Cooke, T. G.
Westley, B. R.
Platt-Higgins, A. M.
Rudland, P. S.
Prognostic significance of cathepsin-D in patients with breast cancer.
title Prognostic significance of cathepsin-D in patients with breast cancer.
title_full Prognostic significance of cathepsin-D in patients with breast cancer.
title_fullStr Prognostic significance of cathepsin-D in patients with breast cancer.
title_full_unstemmed Prognostic significance of cathepsin-D in patients with breast cancer.
title_short Prognostic significance of cathepsin-D in patients with breast cancer.
title_sort prognostic significance of cathepsin-d in patients with breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968341/
https://www.ncbi.nlm.nih.gov/pubmed/8471433
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