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Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria.

Sera from a small sample of adult blood donors, healthy school children and patients with lymphoma, leukaemia, non-haematologic cancer, congenital and inflammatory disorders from Ibadan, Nigeria were screened for HTLV-I antibody by an enzyme-linked immunoabsorbent assay and confirmed by investigatio...

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Autores principales: Williams, C. K., Alexander, S. S., Bodner, A., Levine, A., Saxinger, C., Gallo, R. C., Blattner, W. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968344/
https://www.ncbi.nlm.nih.gov/pubmed/8471436
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author Williams, C. K.
Alexander, S. S.
Bodner, A.
Levine, A.
Saxinger, C.
Gallo, R. C.
Blattner, W. A.
author_facet Williams, C. K.
Alexander, S. S.
Bodner, A.
Levine, A.
Saxinger, C.
Gallo, R. C.
Blattner, W. A.
author_sort Williams, C. K.
collection PubMed
description Sera from a small sample of adult blood donors, healthy school children and patients with lymphoma, leukaemia, non-haematologic cancer, congenital and inflammatory disorders from Ibadan, Nigeria were screened for HTLV-I antibody by an enzyme-linked immunoabsorbent assay and confirmed by investigational Western blot. Seventy-nine of 236 positively screened samples could not be tested for confirmation. Seropositive reactivity was observed in nine of 123 blood donors, and 3 of 46 healthy school children but banding patterns on Western blot were often sparse. Among non-Burkitt's non Hodgkin's lymphoma patients six of 30 were HTLV-I positive including four of four with clinical features of adult T-cell leukaemia (ATL). Other clinical conditions had a frequency of positivity indistinguishable from healthy donors. Western blot patterns ranged from strong with multiple bands, which were uncommon, to those with only p24 and p21 envelope positive which were frequent. Given the relative paucity of clinical ATL and the unusual Western blot patterns the true rate of HTLV-I infection may be lower than estimated. It is possible that a cross-reactive HTLV-I-like virus accounts for this pattern.
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spelling pubmed-19683442009-09-10 Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria. Williams, C. K. Alexander, S. S. Bodner, A. Levine, A. Saxinger, C. Gallo, R. C. Blattner, W. A. Br J Cancer Research Article Sera from a small sample of adult blood donors, healthy school children and patients with lymphoma, leukaemia, non-haematologic cancer, congenital and inflammatory disorders from Ibadan, Nigeria were screened for HTLV-I antibody by an enzyme-linked immunoabsorbent assay and confirmed by investigational Western blot. Seventy-nine of 236 positively screened samples could not be tested for confirmation. Seropositive reactivity was observed in nine of 123 blood donors, and 3 of 46 healthy school children but banding patterns on Western blot were often sparse. Among non-Burkitt's non Hodgkin's lymphoma patients six of 30 were HTLV-I positive including four of four with clinical features of adult T-cell leukaemia (ATL). Other clinical conditions had a frequency of positivity indistinguishable from healthy donors. Western blot patterns ranged from strong with multiple bands, which were uncommon, to those with only p24 and p21 envelope positive which were frequent. Given the relative paucity of clinical ATL and the unusual Western blot patterns the true rate of HTLV-I infection may be lower than estimated. It is possible that a cross-reactive HTLV-I-like virus accounts for this pattern. Nature Publishing Group 1993-04 /pmc/articles/PMC1968344/ /pubmed/8471436 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Williams, C. K.
Alexander, S. S.
Bodner, A.
Levine, A.
Saxinger, C.
Gallo, R. C.
Blattner, W. A.
Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria.
title Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria.
title_full Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria.
title_fullStr Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria.
title_full_unstemmed Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria.
title_short Frequency of adult T-cell leukaemia/lymphoma and HTLV-I in Ibadan, Nigeria.
title_sort frequency of adult t-cell leukaemia/lymphoma and htlv-i in ibadan, nigeria.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968344/
https://www.ncbi.nlm.nih.gov/pubmed/8471436
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