Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours.

Non-thyroid neoplasia were analysed by Southern blot of genomic DNA and DNA prepared by reverse transcription and amplification by polymerase chain reaction (RT/PCR) for the activation of the RET oncogene. It is known that the rearrangement of RET occurs in about 10%-20% of human thyroid papillary c...

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Autores principales: Santoro, M., Sabino, N., Ishizaka, Y., Ushijima, T., Carlomagno, F., Cerrato, A., Grieco, M., Battaglia, C., Martelli, M. L., Paulin, C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968385/
https://www.ncbi.nlm.nih.gov/pubmed/8353035
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author Santoro, M.
Sabino, N.
Ishizaka, Y.
Ushijima, T.
Carlomagno, F.
Cerrato, A.
Grieco, M.
Battaglia, C.
Martelli, M. L.
Paulin, C.
author_facet Santoro, M.
Sabino, N.
Ishizaka, Y.
Ushijima, T.
Carlomagno, F.
Cerrato, A.
Grieco, M.
Battaglia, C.
Martelli, M. L.
Paulin, C.
author_sort Santoro, M.
collection PubMed
description Non-thyroid neoplasia were analysed by Southern blot of genomic DNA and DNA prepared by reverse transcription and amplification by polymerase chain reaction (RT/PCR) for the activation of the RET oncogene. It is known that the rearrangement of RET occurs in about 10%-20% of human thyroid papillary carcinomas. None of 528 non-thyroid tumours showed rearrangement of the RET proto-oncogene, whereas three out of 30 thyroid papillary carcinomas were positive for RET activation. Therefore the activation of RET seems to be a somatic cell mutation specific to human thyroid carcinomas. IMAGES:
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spelling pubmed-19683852009-09-10 Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours. Santoro, M. Sabino, N. Ishizaka, Y. Ushijima, T. Carlomagno, F. Cerrato, A. Grieco, M. Battaglia, C. Martelli, M. L. Paulin, C. Br J Cancer Research Article Non-thyroid neoplasia were analysed by Southern blot of genomic DNA and DNA prepared by reverse transcription and amplification by polymerase chain reaction (RT/PCR) for the activation of the RET oncogene. It is known that the rearrangement of RET occurs in about 10%-20% of human thyroid papillary carcinomas. None of 528 non-thyroid tumours showed rearrangement of the RET proto-oncogene, whereas three out of 30 thyroid papillary carcinomas were positive for RET activation. Therefore the activation of RET seems to be a somatic cell mutation specific to human thyroid carcinomas. IMAGES: Nature Publishing Group 1993-09 /pmc/articles/PMC1968385/ /pubmed/8353035 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Santoro, M.
Sabino, N.
Ishizaka, Y.
Ushijima, T.
Carlomagno, F.
Cerrato, A.
Grieco, M.
Battaglia, C.
Martelli, M. L.
Paulin, C.
Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours.
title Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours.
title_full Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours.
title_fullStr Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours.
title_full_unstemmed Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours.
title_short Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours.
title_sort involvement of ret oncogene in human tumours: specificity of ret activation to thyroid tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968385/
https://www.ncbi.nlm.nih.gov/pubmed/8353035
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