The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck.

We have examined the incidence of Harvey ras mutations in human squamous cell carcinomas (SCC) of the upper aerodigestive tract using the polymerase chain reaction (PCR) followed by direct sequencing. No mutations were detected at codons 12, 13, 59 or 61 of this gene in any of six papillomas, five e...

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Autores principales: Clark, L. J., Edington, K., Swan, I. R., McLay, K. A., Newlands, W. J., Wills, L. C., Young, H. A., Johnston, P. W., Mitchell, R., Robertson, G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968389/
https://www.ncbi.nlm.nih.gov/pubmed/8353052
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author Clark, L. J.
Edington, K.
Swan, I. R.
McLay, K. A.
Newlands, W. J.
Wills, L. C.
Young, H. A.
Johnston, P. W.
Mitchell, R.
Robertson, G.
author_facet Clark, L. J.
Edington, K.
Swan, I. R.
McLay, K. A.
Newlands, W. J.
Wills, L. C.
Young, H. A.
Johnston, P. W.
Mitchell, R.
Robertson, G.
author_sort Clark, L. J.
collection PubMed
description We have examined the incidence of Harvey ras mutations in human squamous cell carcinomas (SCC) of the upper aerodigestive tract using the polymerase chain reaction (PCR) followed by direct sequencing. No mutations were detected at codons 12, 13, 59 or 61 of this gene in any of six papillomas, five erythroplakias, 56 squamous cell carcinomas, and 16 SCC cell lines. Some of the SCC were lymph node metastases (three) or tumours which had recurred following radiotherapy (seven). We conclude that Harvey ras mutations are not a common event in the pathogenesis or recurrence of SCCs from Caucasian subjects, in contrast to the situation with Indian populations (Saranath et al., 1991). IMAGES:
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spelling pubmed-19683892009-09-10 The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck. Clark, L. J. Edington, K. Swan, I. R. McLay, K. A. Newlands, W. J. Wills, L. C. Young, H. A. Johnston, P. W. Mitchell, R. Robertson, G. Br J Cancer Research Article We have examined the incidence of Harvey ras mutations in human squamous cell carcinomas (SCC) of the upper aerodigestive tract using the polymerase chain reaction (PCR) followed by direct sequencing. No mutations were detected at codons 12, 13, 59 or 61 of this gene in any of six papillomas, five erythroplakias, 56 squamous cell carcinomas, and 16 SCC cell lines. Some of the SCC were lymph node metastases (three) or tumours which had recurred following radiotherapy (seven). We conclude that Harvey ras mutations are not a common event in the pathogenesis or recurrence of SCCs from Caucasian subjects, in contrast to the situation with Indian populations (Saranath et al., 1991). IMAGES: Nature Publishing Group 1993-09 /pmc/articles/PMC1968389/ /pubmed/8353052 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Clark, L. J.
Edington, K.
Swan, I. R.
McLay, K. A.
Newlands, W. J.
Wills, L. C.
Young, H. A.
Johnston, P. W.
Mitchell, R.
Robertson, G.
The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck.
title The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck.
title_full The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck.
title_fullStr The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck.
title_full_unstemmed The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck.
title_short The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck.
title_sort absence of harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968389/
https://www.ncbi.nlm.nih.gov/pubmed/8353052
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