Expression of a suppressive p15E-related epitope in colorectal and gastric cancer.

mRNA for the suppressive epitope of p15E was found to be present in 24 of 30 samples of human colorectal cancer and in all four specimens of gastric cancer. mRNA for p15E was seldom seen in nonmalignant colonic or gastric mucosa but, when present, was associated with inflammatory or pre-malignant co...

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Autores principales: Foulds, S., Wakefield, C. H., Giles, M., Gillespie, J., Dye, J. F., Guillou, P. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968406/
https://www.ncbi.nlm.nih.gov/pubmed/7688979
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author Foulds, S.
Wakefield, C. H.
Giles, M.
Gillespie, J.
Dye, J. F.
Guillou, P. J.
author_facet Foulds, S.
Wakefield, C. H.
Giles, M.
Gillespie, J.
Dye, J. F.
Guillou, P. J.
author_sort Foulds, S.
collection PubMed
description mRNA for the suppressive epitope of p15E was found to be present in 24 of 30 samples of human colorectal cancer and in all four specimens of gastric cancer. mRNA for p15E was seldom seen in nonmalignant colonic or gastric mucosa but, when present, was associated with inflammatory or pre-malignant conditions of the digestive tract. Synthetic peptides derived from the conserved p15E sequence were found to suppress some aspects of the immune response implicated in anti-tumour activity. These data suggest that a p15E-related material with immunomodulatory properties is elaborated within human tumours, either by the tumour itself or as a normal component of the endogenous anti-tumour reaction. IMAGES:
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spelling pubmed-19684062009-09-10 Expression of a suppressive p15E-related epitope in colorectal and gastric cancer. Foulds, S. Wakefield, C. H. Giles, M. Gillespie, J. Dye, J. F. Guillou, P. J. Br J Cancer Research Article mRNA for the suppressive epitope of p15E was found to be present in 24 of 30 samples of human colorectal cancer and in all four specimens of gastric cancer. mRNA for p15E was seldom seen in nonmalignant colonic or gastric mucosa but, when present, was associated with inflammatory or pre-malignant conditions of the digestive tract. Synthetic peptides derived from the conserved p15E sequence were found to suppress some aspects of the immune response implicated in anti-tumour activity. These data suggest that a p15E-related material with immunomodulatory properties is elaborated within human tumours, either by the tumour itself or as a normal component of the endogenous anti-tumour reaction. IMAGES: Nature Publishing Group 1993-09 /pmc/articles/PMC1968406/ /pubmed/7688979 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Foulds, S.
Wakefield, C. H.
Giles, M.
Gillespie, J.
Dye, J. F.
Guillou, P. J.
Expression of a suppressive p15E-related epitope in colorectal and gastric cancer.
title Expression of a suppressive p15E-related epitope in colorectal and gastric cancer.
title_full Expression of a suppressive p15E-related epitope in colorectal and gastric cancer.
title_fullStr Expression of a suppressive p15E-related epitope in colorectal and gastric cancer.
title_full_unstemmed Expression of a suppressive p15E-related epitope in colorectal and gastric cancer.
title_short Expression of a suppressive p15E-related epitope in colorectal and gastric cancer.
title_sort expression of a suppressive p15e-related epitope in colorectal and gastric cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968406/
https://www.ncbi.nlm.nih.gov/pubmed/7688979
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