Molecular alterations in a patient with Turcot's syndrome.

Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary...

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Autores principales: Rochlitz, C. F., Heide, I., de Kant, E., Neubauer, A., Schmidt, C. A., Neuhaus, P., Huhn, D., Herrmann, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968408/
https://www.ncbi.nlm.nih.gov/pubmed/8394730
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author Rochlitz, C. F.
Heide, I.
de Kant, E.
Neubauer, A.
Schmidt, C. A.
Neuhaus, P.
Huhn, D.
Herrmann, R.
author_facet Rochlitz, C. F.
Heide, I.
de Kant, E.
Neubauer, A.
Schmidt, C. A.
Neuhaus, P.
Huhn, D.
Herrmann, R.
author_sort Rochlitz, C. F.
collection PubMed
description Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour but not in the germline of the patient nor in her parents. IMAGES:
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spelling pubmed-19684082009-09-10 Molecular alterations in a patient with Turcot's syndrome. Rochlitz, C. F. Heide, I. de Kant, E. Neubauer, A. Schmidt, C. A. Neuhaus, P. Huhn, D. Herrmann, R. Br J Cancer Research Article Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations of the Ki-ras gene were detected in primary and metastatic tumour but not in the germline of the patient nor in her parents. IMAGES: Nature Publishing Group 1993-09 /pmc/articles/PMC1968408/ /pubmed/8394730 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Rochlitz, C. F.
Heide, I.
de Kant, E.
Neubauer, A.
Schmidt, C. A.
Neuhaus, P.
Huhn, D.
Herrmann, R.
Molecular alterations in a patient with Turcot's syndrome.
title Molecular alterations in a patient with Turcot's syndrome.
title_full Molecular alterations in a patient with Turcot's syndrome.
title_fullStr Molecular alterations in a patient with Turcot's syndrome.
title_full_unstemmed Molecular alterations in a patient with Turcot's syndrome.
title_short Molecular alterations in a patient with Turcot's syndrome.
title_sort molecular alterations in a patient with turcot's syndrome.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968408/
https://www.ncbi.nlm.nih.gov/pubmed/8394730
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