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Mortality of a cohort of French uranium miners exposed to relatively low radon concentrations.

A cohort mortality study has been performed on French uranium miners having experienced more than 2 years of underground mining, with first radon exposure between 1946 and 1972. Vital status has been ascertained from the date of entry to the 31 December 1985 for 99% of the members of this cohort; ca...

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Autores principales: Tirmarche, M., Raphalen, A., Allin, F., Chameaud, J., Bredon, P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968425/
https://www.ncbi.nlm.nih.gov/pubmed/8494704
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author Tirmarche, M.
Raphalen, A.
Allin, F.
Chameaud, J.
Bredon, P.
author_facet Tirmarche, M.
Raphalen, A.
Allin, F.
Chameaud, J.
Bredon, P.
author_sort Tirmarche, M.
collection PubMed
description A cohort mortality study has been performed on French uranium miners having experienced more than 2 years of underground mining, with first radon exposure between 1946 and 1972. Vital status has been ascertained from the date of entry to the 31 December 1985 for 99% of the members of this cohort; causes of death are identified for 95.5% of the decedents. The different causes of death are compared to the age specific national death rates by indirect standardisation and expressed by standardised mortality ratios (SMR). A statistically significant excess has been observed for lung and laryngeal cancer deaths. The Poisson trend test shows a statistically significant trend for the risk of lung cancer death as a function of cumulative radon exposure, assuming a lag time of 5 years; for laryngeal cancer no significant trend has been observed. Poisson regression modelling has been applied to the following exposure groups: < 10 WLM (Working Level Month); 10-49 WLM; 50-149 WLM; 150-299 WLM; > or = 300 WLM; it indicates an increase in the SMR for lung cancer of 0.6% per WLM (standard error: 0.4%) with an estimated intercept at 0 WLM of 1.68 (standard error: 0.4). The distinction of two working periods, differing by their annual radon concentration (before/since 1956) does not modify this exposure-response relationship. This coefficient of risk per unit of exposure is lower than in most of the other uranium miners' studies but it lies in the range of the evaluation of the ICRP 50 committee and the 'BEIR IV' report of the U.S. National Academy of Science. It is observed in a cohort having experienced low cumulative exposure to radon (mean: 70 WLM) spread over a mean duration of 14.5 years. Even though occupational exposure in mines differs in several particulars from domestic exposure, this study presents characteristics of low annual exposure comparable to radon gas concentrations in houses of 500-1000 Bq.m-3, and will contribute to the evaluation of cancer risk for the public.
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spelling pubmed-19684252009-09-10 Mortality of a cohort of French uranium miners exposed to relatively low radon concentrations. Tirmarche, M. Raphalen, A. Allin, F. Chameaud, J. Bredon, P. Br J Cancer Research Article A cohort mortality study has been performed on French uranium miners having experienced more than 2 years of underground mining, with first radon exposure between 1946 and 1972. Vital status has been ascertained from the date of entry to the 31 December 1985 for 99% of the members of this cohort; causes of death are identified for 95.5% of the decedents. The different causes of death are compared to the age specific national death rates by indirect standardisation and expressed by standardised mortality ratios (SMR). A statistically significant excess has been observed for lung and laryngeal cancer deaths. The Poisson trend test shows a statistically significant trend for the risk of lung cancer death as a function of cumulative radon exposure, assuming a lag time of 5 years; for laryngeal cancer no significant trend has been observed. Poisson regression modelling has been applied to the following exposure groups: < 10 WLM (Working Level Month); 10-49 WLM; 50-149 WLM; 150-299 WLM; > or = 300 WLM; it indicates an increase in the SMR for lung cancer of 0.6% per WLM (standard error: 0.4%) with an estimated intercept at 0 WLM of 1.68 (standard error: 0.4). The distinction of two working periods, differing by their annual radon concentration (before/since 1956) does not modify this exposure-response relationship. This coefficient of risk per unit of exposure is lower than in most of the other uranium miners' studies but it lies in the range of the evaluation of the ICRP 50 committee and the 'BEIR IV' report of the U.S. National Academy of Science. It is observed in a cohort having experienced low cumulative exposure to radon (mean: 70 WLM) spread over a mean duration of 14.5 years. Even though occupational exposure in mines differs in several particulars from domestic exposure, this study presents characteristics of low annual exposure comparable to radon gas concentrations in houses of 500-1000 Bq.m-3, and will contribute to the evaluation of cancer risk for the public. Nature Publishing Group 1993-05 /pmc/articles/PMC1968425/ /pubmed/8494704 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Tirmarche, M.
Raphalen, A.
Allin, F.
Chameaud, J.
Bredon, P.
Mortality of a cohort of French uranium miners exposed to relatively low radon concentrations.
title Mortality of a cohort of French uranium miners exposed to relatively low radon concentrations.
title_full Mortality of a cohort of French uranium miners exposed to relatively low radon concentrations.
title_fullStr Mortality of a cohort of French uranium miners exposed to relatively low radon concentrations.
title_full_unstemmed Mortality of a cohort of French uranium miners exposed to relatively low radon concentrations.
title_short Mortality of a cohort of French uranium miners exposed to relatively low radon concentrations.
title_sort mortality of a cohort of french uranium miners exposed to relatively low radon concentrations.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968425/
https://www.ncbi.nlm.nih.gov/pubmed/8494704
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