Loss of constitutional heterozygosity on chromosomes 5 and 17 in cholangiocarcinoma.

It has been established that loss of tumour suppressor genes is crucial in carcinogenesis. There has been no reported study on searching for tumour suppressor genes in cholangiocarcinomas as yet. In order to investigate the loss of heterozygosity (LOH), which may represent such gene loss, in cholang...

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Autores principales: Ding, S. F., Delhanty, J. D., Bowles, L., Dooley, J. S., Wood, C. B., Habib, N. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968440/
https://www.ncbi.nlm.nih.gov/pubmed/8388228
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author Ding, S. F.
Delhanty, J. D.
Bowles, L.
Dooley, J. S.
Wood, C. B.
Habib, N. A.
author_facet Ding, S. F.
Delhanty, J. D.
Bowles, L.
Dooley, J. S.
Wood, C. B.
Habib, N. A.
author_sort Ding, S. F.
collection PubMed
description It has been established that loss of tumour suppressor genes is crucial in carcinogenesis. There has been no reported study on searching for tumour suppressor genes in cholangiocarcinomas as yet. In order to investigate the loss of heterozygosity (LOH), which may represent such gene loss, in cholangiocarcinoma, we studied 14 patients with this tumour using restriction fragment length polymorphism analysis. Twenty-two probes assigned to chromosomes 1, 5, 7, 9, 11, 12, 13, 14, 16, 17 and 18 were used. Allelic losses were found in chromosomal regions 5q35-qter and 17p13. Loss of genetic material in these regions in cholangiocarcinoma was shared with hepatocellular carcinoma. Probes for other chromosomes have as yet shown no consistent LOH. In conclusion, this study for the first time showed LOH on chromosomes 5 and 17 in cholangiocarcinoma. IMAGES:
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spelling pubmed-19684402009-09-10 Loss of constitutional heterozygosity on chromosomes 5 and 17 in cholangiocarcinoma. Ding, S. F. Delhanty, J. D. Bowles, L. Dooley, J. S. Wood, C. B. Habib, N. A. Br J Cancer Research Article It has been established that loss of tumour suppressor genes is crucial in carcinogenesis. There has been no reported study on searching for tumour suppressor genes in cholangiocarcinomas as yet. In order to investigate the loss of heterozygosity (LOH), which may represent such gene loss, in cholangiocarcinoma, we studied 14 patients with this tumour using restriction fragment length polymorphism analysis. Twenty-two probes assigned to chromosomes 1, 5, 7, 9, 11, 12, 13, 14, 16, 17 and 18 were used. Allelic losses were found in chromosomal regions 5q35-qter and 17p13. Loss of genetic material in these regions in cholangiocarcinoma was shared with hepatocellular carcinoma. Probes for other chromosomes have as yet shown no consistent LOH. In conclusion, this study for the first time showed LOH on chromosomes 5 and 17 in cholangiocarcinoma. IMAGES: Nature Publishing Group 1993-05 /pmc/articles/PMC1968440/ /pubmed/8388228 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ding, S. F.
Delhanty, J. D.
Bowles, L.
Dooley, J. S.
Wood, C. B.
Habib, N. A.
Loss of constitutional heterozygosity on chromosomes 5 and 17 in cholangiocarcinoma.
title Loss of constitutional heterozygosity on chromosomes 5 and 17 in cholangiocarcinoma.
title_full Loss of constitutional heterozygosity on chromosomes 5 and 17 in cholangiocarcinoma.
title_fullStr Loss of constitutional heterozygosity on chromosomes 5 and 17 in cholangiocarcinoma.
title_full_unstemmed Loss of constitutional heterozygosity on chromosomes 5 and 17 in cholangiocarcinoma.
title_short Loss of constitutional heterozygosity on chromosomes 5 and 17 in cholangiocarcinoma.
title_sort loss of constitutional heterozygosity on chromosomes 5 and 17 in cholangiocarcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968440/
https://www.ncbi.nlm.nih.gov/pubmed/8388228
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