Lack of nephrotoxicity of oral ammine/amine platinum (IV) dicarboxylate complexes in rodents.

The comparative nephrotoxicity of i.v. cisplatin, i.v. carboplatin and six p.o. ammine/amine Pt(IV) dicarboxylates was studied in rodents following single MTD treatments. In mice, i.v. cisplatin caused proteinuria (1 g l-1), glycosuria (16.7 mM) and decreased GFR at 4 days, and histological kidney d...

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Detalles Bibliográficos
Autores principales: McKeage, M. J., Morgan, S. E., Boxall, F. E., Murrer, B. A., Hard, G. C., Harrap, K. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968463/
https://www.ncbi.nlm.nih.gov/pubmed/8494733

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