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Karyotypic abnormalities in tumours of the pancreas.

Short-term cultures from 20 pancreatic tumours, three endocrine and 17 exocrine, were cytogenetically analysed. All three endocrine tumours had a normal chromosome complement. Clonal chromosome aberrations were detected in 13 of the 17 exocrine tumours: simple karyotypic changes were found in five c...

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Autores principales: Bardi, G., Johansson, B., Pandis, N., Mandahl, N., Bak-Jensen, E., Andrén-Sandberg, A., Mitelman, F., Heim, S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968474/
https://www.ncbi.nlm.nih.gov/pubmed/8494707
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author Bardi, G.
Johansson, B.
Pandis, N.
Mandahl, N.
Bak-Jensen, E.
Andrén-Sandberg, A.
Mitelman, F.
Heim, S.
author_facet Bardi, G.
Johansson, B.
Pandis, N.
Mandahl, N.
Bak-Jensen, E.
Andrén-Sandberg, A.
Mitelman, F.
Heim, S.
author_sort Bardi, G.
collection PubMed
description Short-term cultures from 20 pancreatic tumours, three endocrine and 17 exocrine, were cytogenetically analysed. All three endocrine tumours had a normal chromosome complement. Clonal chromosome aberrations were detected in 13 of the 17 exocrine tumours: simple karyotypic changes were found in five carcinomas and numerous numerical and/or structural changes in eight. When the present findings and those previously reported by our group were viewed in conjunction, the most common numerical imbalances among the 22 karyotypically abnormal pancreatic carcinomas thus available for evaluation turned out to be, in order of falling frequency, -18, -Y, +20, +7, +11 and -12. Imbalances brought about by structural changes most frequently affected chromosomes 1 (losses in 1p but especially gains of 1q), 8 (in particular 8q gains but also 8p losses), and 17 (mostly 17q gain but also loss of 17p). Chromosomal bands 1p32, 1q10, 6q21, 7p22, 8p21, 8q11, 14p11, 15q10-11, and 17q11 were the most common breakpoint sites affected by the structural rearrangements. Abnormal karyotypes were detected more frequently in poorly differentiated and anaplastic carcinomas than in moderately and well differentiated tumours. IMAGES:
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spelling pubmed-19684742009-09-10 Karyotypic abnormalities in tumours of the pancreas. Bardi, G. Johansson, B. Pandis, N. Mandahl, N. Bak-Jensen, E. Andrén-Sandberg, A. Mitelman, F. Heim, S. Br J Cancer Research Article Short-term cultures from 20 pancreatic tumours, three endocrine and 17 exocrine, were cytogenetically analysed. All three endocrine tumours had a normal chromosome complement. Clonal chromosome aberrations were detected in 13 of the 17 exocrine tumours: simple karyotypic changes were found in five carcinomas and numerous numerical and/or structural changes in eight. When the present findings and those previously reported by our group were viewed in conjunction, the most common numerical imbalances among the 22 karyotypically abnormal pancreatic carcinomas thus available for evaluation turned out to be, in order of falling frequency, -18, -Y, +20, +7, +11 and -12. Imbalances brought about by structural changes most frequently affected chromosomes 1 (losses in 1p but especially gains of 1q), 8 (in particular 8q gains but also 8p losses), and 17 (mostly 17q gain but also loss of 17p). Chromosomal bands 1p32, 1q10, 6q21, 7p22, 8p21, 8q11, 14p11, 15q10-11, and 17q11 were the most common breakpoint sites affected by the structural rearrangements. Abnormal karyotypes were detected more frequently in poorly differentiated and anaplastic carcinomas than in moderately and well differentiated tumours. IMAGES: Nature Publishing Group 1993-05 /pmc/articles/PMC1968474/ /pubmed/8494707 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Bardi, G.
Johansson, B.
Pandis, N.
Mandahl, N.
Bak-Jensen, E.
Andrén-Sandberg, A.
Mitelman, F.
Heim, S.
Karyotypic abnormalities in tumours of the pancreas.
title Karyotypic abnormalities in tumours of the pancreas.
title_full Karyotypic abnormalities in tumours of the pancreas.
title_fullStr Karyotypic abnormalities in tumours of the pancreas.
title_full_unstemmed Karyotypic abnormalities in tumours of the pancreas.
title_short Karyotypic abnormalities in tumours of the pancreas.
title_sort karyotypic abnormalities in tumours of the pancreas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968474/
https://www.ncbi.nlm.nih.gov/pubmed/8494707
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