High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal.

In hepatocellular carcinoma, mutation within the p53 gene occurs mainly at codon 249 and its frequency has been associated with exposure to aflatoxin. As Senegal is a country where liver cancer incidence is one of the highest in the world and where people are highly exposed to aflatoxin, we screened...

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Autores principales: Coursaget, P., Depril, N., Chabaud, M., Nandi, R., Mayelo, V., LeCann, P., Yvonnet, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968506/
https://www.ncbi.nlm.nih.gov/pubmed/8390289
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author Coursaget, P.
Depril, N.
Chabaud, M.
Nandi, R.
Mayelo, V.
LeCann, P.
Yvonnet, B.
author_facet Coursaget, P.
Depril, N.
Chabaud, M.
Nandi, R.
Mayelo, V.
LeCann, P.
Yvonnet, B.
author_sort Coursaget, P.
collection PubMed
description In hepatocellular carcinoma, mutation within the p53 gene occurs mainly at codon 249 and its frequency has been associated with exposure to aflatoxin. As Senegal is a country where liver cancer incidence is one of the highest in the world and where people are highly exposed to aflatoxin, we screened 15 liver cancer samples from this country for mutation at codon 249 of the p53 gene. Non-tumoral DNA from the patients showed a wild type genotype. Mutation at codon 249 of the p53 gene was detected in 10 of the 15 tumour tissues tested (67%). This frequency of mutation in codon 249 of the p53 gene is the highest described. These results confirmed that there is an association between countries of high aflatoxin intake and a high frequency of mutation in codon 249 of p53 gene, and that HBV alone does not contribute to these base changes. IMAGES:
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spelling pubmed-19685062009-09-10 High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal. Coursaget, P. Depril, N. Chabaud, M. Nandi, R. Mayelo, V. LeCann, P. Yvonnet, B. Br J Cancer Research Article In hepatocellular carcinoma, mutation within the p53 gene occurs mainly at codon 249 and its frequency has been associated with exposure to aflatoxin. As Senegal is a country where liver cancer incidence is one of the highest in the world and where people are highly exposed to aflatoxin, we screened 15 liver cancer samples from this country for mutation at codon 249 of the p53 gene. Non-tumoral DNA from the patients showed a wild type genotype. Mutation at codon 249 of the p53 gene was detected in 10 of the 15 tumour tissues tested (67%). This frequency of mutation in codon 249 of the p53 gene is the highest described. These results confirmed that there is an association between countries of high aflatoxin intake and a high frequency of mutation in codon 249 of p53 gene, and that HBV alone does not contribute to these base changes. IMAGES: Nature Publishing Group 1993-06 /pmc/articles/PMC1968506/ /pubmed/8390289 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Coursaget, P.
Depril, N.
Chabaud, M.
Nandi, R.
Mayelo, V.
LeCann, P.
Yvonnet, B.
High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal.
title High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal.
title_full High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal.
title_fullStr High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal.
title_full_unstemmed High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal.
title_short High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal.
title_sort high prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinomas from senegal.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968506/
https://www.ncbi.nlm.nih.gov/pubmed/8390289
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