Cellular accumulation of the anticancer agent cisplatin: a review.

Acquired resistance to cisplatin (DDP) is a major clinical problem in the treatment of ovarian, testicular, and head and neck carcinomas; decreased accumulation of DDP is the most consistently observed alteration in resistant cells. It has been postulated that DDP enters the cell by passive diffusio...

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Detalles Bibliográficos
Autores principales: Gately, D. P., Howell, S. B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968522/
https://www.ncbi.nlm.nih.gov/pubmed/8512802
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author Gately, D. P.
Howell, S. B.
author_facet Gately, D. P.
Howell, S. B.
author_sort Gately, D. P.
collection PubMed
description Acquired resistance to cisplatin (DDP) is a major clinical problem in the treatment of ovarian, testicular, and head and neck carcinomas; decreased accumulation of DDP is the most consistently observed alteration in resistant cells. It has been postulated that DDP enters the cell by passive diffusion based on the observations that DDP accumulation is proportional to the drug concentration, accumulation is not saturable, and that structural analogs of DDP do not inhibit accumulation. However, recent studies show that DDP accumulation can be specifically stimulated or inhibited by pharmacological agents and the activation of signal transduction pathways. This paper reviews the existing data on the mechanism of DDP accumulation and develops the postulate that some component of transport occurs through a gated ion channel.
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spelling pubmed-19685222009-09-10 Cellular accumulation of the anticancer agent cisplatin: a review. Gately, D. P. Howell, S. B. Br J Cancer Research Article Acquired resistance to cisplatin (DDP) is a major clinical problem in the treatment of ovarian, testicular, and head and neck carcinomas; decreased accumulation of DDP is the most consistently observed alteration in resistant cells. It has been postulated that DDP enters the cell by passive diffusion based on the observations that DDP accumulation is proportional to the drug concentration, accumulation is not saturable, and that structural analogs of DDP do not inhibit accumulation. However, recent studies show that DDP accumulation can be specifically stimulated or inhibited by pharmacological agents and the activation of signal transduction pathways. This paper reviews the existing data on the mechanism of DDP accumulation and develops the postulate that some component of transport occurs through a gated ion channel. Nature Publishing Group 1993-06 /pmc/articles/PMC1968522/ /pubmed/8512802 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Gately, D. P.
Howell, S. B.
Cellular accumulation of the anticancer agent cisplatin: a review.
title Cellular accumulation of the anticancer agent cisplatin: a review.
title_full Cellular accumulation of the anticancer agent cisplatin: a review.
title_fullStr Cellular accumulation of the anticancer agent cisplatin: a review.
title_full_unstemmed Cellular accumulation of the anticancer agent cisplatin: a review.
title_short Cellular accumulation of the anticancer agent cisplatin: a review.
title_sort cellular accumulation of the anticancer agent cisplatin: a review.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968522/
https://www.ncbi.nlm.nih.gov/pubmed/8512802
work_keys_str_mv AT gatelydp cellularaccumulationoftheanticanceragentcisplatinareview
AT howellsb cellularaccumulationoftheanticanceragentcisplatinareview

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