Lymphocyte homing receptor (CD44) expression is associated with poor prognosis in gastrointestinal lymphoma.

Lymphocyte homing receptor (CD44) is involved in lymphocyte adhesion to endothelial cells of high endothelial venules (HEVs) and lymphocyte exit from the blood circulation, and it may be involved also in hematogenous dissemination of malignant lymphoma. Prognostic significance of lymphocyte homing r...

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Autores principales: Joensuu, H., Ristamäki, R., Klemi, P. J., Jalkanen, S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968534/
https://www.ncbi.nlm.nih.gov/pubmed/8347502
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author Joensuu, H.
Ristamäki, R.
Klemi, P. J.
Jalkanen, S.
author_facet Joensuu, H.
Ristamäki, R.
Klemi, P. J.
Jalkanen, S.
author_sort Joensuu, H.
collection PubMed
description Lymphocyte homing receptor (CD44) is involved in lymphocyte adhesion to endothelial cells of high endothelial venules (HEVs) and lymphocyte exit from the blood circulation, and it may be involved also in hematogenous dissemination of malignant lymphoma. Prognostic significance of lymphocyte homing receptor expression defined by Hermes-3 antibody was studied among 27 gastrointestinal lymphomas followed up for 8 to 20 years after the diagnosis. Lymphomas lacking or with very weak homing receptor expression (n = 14, 52%) were associated with 57% 10-year survival rate as compared with only 15% among lymphomas that expressed CD44 more strongly (P = 0.02). We conclude that lack of lymphocyte homing receptor expression is common in gastrointestinal lymphoma, and that CD44 expression is associated with unfavourable prognosis. IMAGES:
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spelling pubmed-19685342009-09-10 Lymphocyte homing receptor (CD44) expression is associated with poor prognosis in gastrointestinal lymphoma. Joensuu, H. Ristamäki, R. Klemi, P. J. Jalkanen, S. Br J Cancer Research Article Lymphocyte homing receptor (CD44) is involved in lymphocyte adhesion to endothelial cells of high endothelial venules (HEVs) and lymphocyte exit from the blood circulation, and it may be involved also in hematogenous dissemination of malignant lymphoma. Prognostic significance of lymphocyte homing receptor expression defined by Hermes-3 antibody was studied among 27 gastrointestinal lymphomas followed up for 8 to 20 years after the diagnosis. Lymphomas lacking or with very weak homing receptor expression (n = 14, 52%) were associated with 57% 10-year survival rate as compared with only 15% among lymphomas that expressed CD44 more strongly (P = 0.02). We conclude that lack of lymphocyte homing receptor expression is common in gastrointestinal lymphoma, and that CD44 expression is associated with unfavourable prognosis. IMAGES: Nature Publishing Group 1993-08 /pmc/articles/PMC1968534/ /pubmed/8347502 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Joensuu, H.
Ristamäki, R.
Klemi, P. J.
Jalkanen, S.
Lymphocyte homing receptor (CD44) expression is associated with poor prognosis in gastrointestinal lymphoma.
title Lymphocyte homing receptor (CD44) expression is associated with poor prognosis in gastrointestinal lymphoma.
title_full Lymphocyte homing receptor (CD44) expression is associated with poor prognosis in gastrointestinal lymphoma.
title_fullStr Lymphocyte homing receptor (CD44) expression is associated with poor prognosis in gastrointestinal lymphoma.
title_full_unstemmed Lymphocyte homing receptor (CD44) expression is associated with poor prognosis in gastrointestinal lymphoma.
title_short Lymphocyte homing receptor (CD44) expression is associated with poor prognosis in gastrointestinal lymphoma.
title_sort lymphocyte homing receptor (cd44) expression is associated with poor prognosis in gastrointestinal lymphoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968534/
https://www.ncbi.nlm.nih.gov/pubmed/8347502
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