Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture).

The retinoblastoma gene product (RB) contributes to normal cell growth control. One of its functions is manifest as a block to exit from G1, which is carried out by an RB subspecies which is un- or underphosphorylated. After RB phosphorylation, a process which occurs towards the end of G1 in cycling...

Descripción completa

Detalles Bibliográficos
Autores principales: Livingston, D. M., Kaelin, W., Chittenden, T., Qin, X.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968582/
https://www.ncbi.nlm.nih.gov/pubmed/8347480
_version_ 1782134771880558592
author Livingston, D. M.
Kaelin, W.
Chittenden, T.
Qin, X.
author_facet Livingston, D. M.
Kaelin, W.
Chittenden, T.
Qin, X.
author_sort Livingston, D. M.
collection PubMed
description The retinoblastoma gene product (RB) contributes to normal cell growth control. One of its functions is manifest as a block to exit from G1, which is carried out by an RB subspecies which is un- or underphosphorylated. After RB phosphorylation, a process which occurs towards the end of G1 in cycling cells, the block is lifted allowing a cell to enter S. Here, we review a series of results which speak to the elements of RB structure which contribute to this activity. Included is its internal colinear protein receptor domain (i.e. the 'pocket'). IMAGES:
format Text
id pubmed-1968582
institution National Center for Biotechnology Information
language English
publishDate 1993
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-19685822009-09-10 Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture). Livingston, D. M. Kaelin, W. Chittenden, T. Qin, X. Br J Cancer Research Article The retinoblastoma gene product (RB) contributes to normal cell growth control. One of its functions is manifest as a block to exit from G1, which is carried out by an RB subspecies which is un- or underphosphorylated. After RB phosphorylation, a process which occurs towards the end of G1 in cycling cells, the block is lifted allowing a cell to enter S. Here, we review a series of results which speak to the elements of RB structure which contribute to this activity. Included is its internal colinear protein receptor domain (i.e. the 'pocket'). IMAGES: Nature Publishing Group 1993-08 /pmc/articles/PMC1968582/ /pubmed/8347480 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Livingston, D. M.
Kaelin, W.
Chittenden, T.
Qin, X.
Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture).
title Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture).
title_full Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture).
title_fullStr Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture).
title_full_unstemmed Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture).
title_short Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture).
title_sort structural and functional contributions to the g1 blocking action of the retinoblastoma protein. (the 1992 gordon hamilton fairley memorial lecture).
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968582/
https://www.ncbi.nlm.nih.gov/pubmed/8347480
work_keys_str_mv AT livingstondm structuralandfunctionalcontributionstotheg1blockingactionoftheretinoblastomaproteinthe1992gordonhamiltonfairleymemoriallecture
AT kaelinw structuralandfunctionalcontributionstotheg1blockingactionoftheretinoblastomaproteinthe1992gordonhamiltonfairleymemoriallecture
AT chittendent structuralandfunctionalcontributionstotheg1blockingactionoftheretinoblastomaproteinthe1992gordonhamiltonfairleymemoriallecture
AT qinx structuralandfunctionalcontributionstotheg1blockingactionoftheretinoblastomaproteinthe1992gordonhamiltonfairleymemoriallecture

Ejemplares similares