The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells.

We have observed that low pH can substantially potentiate the cytotoxic effect of the bioreductive drug SR4233 in aerobic HT-29 human tumour cells. No such potentiation was observed under hypoxic conditions. This pH effect might be relevant both to the therapeutic effectiveness and to the normal tis...

Descripción completa

Detalles Bibliográficos
Autores principales: Skarsgard, L. D., Skwarchuk, M. W., Vinczan, A., Chaplin, D. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968590/
https://www.ncbi.nlm.nih.gov/pubmed/8398693
_version_ 1782134773644263424
author Skarsgard, L. D.
Skwarchuk, M. W.
Vinczan, A.
Chaplin, D. J.
author_facet Skarsgard, L. D.
Skwarchuk, M. W.
Vinczan, A.
Chaplin, D. J.
author_sort Skarsgard, L. D.
collection PubMed
description We have observed that low pH can substantially potentiate the cytotoxic effect of the bioreductive drug SR4233 in aerobic HT-29 human tumour cells. No such potentiation was observed under hypoxic conditions. This pH effect might be relevant both to the therapeutic effectiveness and to the normal tissue toxicity of this new agent.
format Text
id pubmed-1968590
institution National Center for Biotechnology Information
language English
publishDate 1993
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-19685902009-09-10 The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells. Skarsgard, L. D. Skwarchuk, M. W. Vinczan, A. Chaplin, D. J. Br J Cancer Research Article We have observed that low pH can substantially potentiate the cytotoxic effect of the bioreductive drug SR4233 in aerobic HT-29 human tumour cells. No such potentiation was observed under hypoxic conditions. This pH effect might be relevant both to the therapeutic effectiveness and to the normal tissue toxicity of this new agent. Nature Publishing Group 1993-10 /pmc/articles/PMC1968590/ /pubmed/8398693 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Skarsgard, L. D.
Skwarchuk, M. W.
Vinczan, A.
Chaplin, D. J.
The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells.
title The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells.
title_full The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells.
title_fullStr The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells.
title_full_unstemmed The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells.
title_short The effect of pH on the aerobic and hypoxic cytotoxicity of SR4233 in HT-29 cells.
title_sort effect of ph on the aerobic and hypoxic cytotoxicity of sr4233 in ht-29 cells.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968590/
https://www.ncbi.nlm.nih.gov/pubmed/8398693
work_keys_str_mv AT skarsgardld theeffectofphontheaerobicandhypoxiccytotoxicityofsr4233inht29cells
AT skwarchukmw theeffectofphontheaerobicandhypoxiccytotoxicityofsr4233inht29cells
AT vinczana theeffectofphontheaerobicandhypoxiccytotoxicityofsr4233inht29cells
AT chaplindj theeffectofphontheaerobicandhypoxiccytotoxicityofsr4233inht29cells
AT skarsgardld effectofphontheaerobicandhypoxiccytotoxicityofsr4233inht29cells
AT skwarchukmw effectofphontheaerobicandhypoxiccytotoxicityofsr4233inht29cells
AT vinczana effectofphontheaerobicandhypoxiccytotoxicityofsr4233inht29cells
AT chaplindj effectofphontheaerobicandhypoxiccytotoxicityofsr4233inht29cells

Ejemplares similares