Prognostic impact of EGF-receptor in papillary thyroid carcinoma.

In this study of papillary thyroid carcinomas, immunopositivity for EGF-receptor was present in a majority of the cases (96%), although different staining patterns were observed. A distinct membraneous reaction was found in 46%, whereas cytoplasmatic positivity of various degrees was present in 90%...

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Autores principales: Akslen, L. A., Myking, A. O., Salvesen, H., Varhaug, J. E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968597/
https://www.ncbi.nlm.nih.gov/pubmed/8398712
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author Akslen, L. A.
Myking, A. O.
Salvesen, H.
Varhaug, J. E.
author_facet Akslen, L. A.
Myking, A. O.
Salvesen, H.
Varhaug, J. E.
author_sort Akslen, L. A.
collection PubMed
description In this study of papillary thyroid carcinomas, immunopositivity for EGF-receptor was present in a majority of the cases (96%), although different staining patterns were observed. A distinct membraneous reaction was found in 46%, whereas cytoplasmatic positivity of various degrees was present in 90% of the cases. Strong cytoplasmic EGF-receptor staining was significantly associated with extra-thyroidal growth of the primary tumour (P = 0.009), and it was furthermore related to decreased recurrence free survival (P = 0.006). Membraneous EGF-receptor staining was not associated with recurrence free survival or patient survival. Multivariate Cox analysis showed that lymph node metastases (P = 0.0009) and cytoplasmic EGF-receptor staining (P = 0.0048) was independent indicators of tumour recurrences in this group of surgically treated papillary thyroid carcinomas. IMAGES:
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spelling pubmed-19685972009-09-10 Prognostic impact of EGF-receptor in papillary thyroid carcinoma. Akslen, L. A. Myking, A. O. Salvesen, H. Varhaug, J. E. Br J Cancer Research Article In this study of papillary thyroid carcinomas, immunopositivity for EGF-receptor was present in a majority of the cases (96%), although different staining patterns were observed. A distinct membraneous reaction was found in 46%, whereas cytoplasmatic positivity of various degrees was present in 90% of the cases. Strong cytoplasmic EGF-receptor staining was significantly associated with extra-thyroidal growth of the primary tumour (P = 0.009), and it was furthermore related to decreased recurrence free survival (P = 0.006). Membraneous EGF-receptor staining was not associated with recurrence free survival or patient survival. Multivariate Cox analysis showed that lymph node metastases (P = 0.0009) and cytoplasmic EGF-receptor staining (P = 0.0048) was independent indicators of tumour recurrences in this group of surgically treated papillary thyroid carcinomas. IMAGES: Nature Publishing Group 1993-10 /pmc/articles/PMC1968597/ /pubmed/8398712 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Akslen, L. A.
Myking, A. O.
Salvesen, H.
Varhaug, J. E.
Prognostic impact of EGF-receptor in papillary thyroid carcinoma.
title Prognostic impact of EGF-receptor in papillary thyroid carcinoma.
title_full Prognostic impact of EGF-receptor in papillary thyroid carcinoma.
title_fullStr Prognostic impact of EGF-receptor in papillary thyroid carcinoma.
title_full_unstemmed Prognostic impact of EGF-receptor in papillary thyroid carcinoma.
title_short Prognostic impact of EGF-receptor in papillary thyroid carcinoma.
title_sort prognostic impact of egf-receptor in papillary thyroid carcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968597/
https://www.ncbi.nlm.nih.gov/pubmed/8398712
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