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In vitro antitumour activity of cis- and trans-5-fluoro-5,6-dihydro-6-alkoxy-uracils; effects on thymidylate synthesis.

A class of new 5-fluorouracil (FU) analogues, the 5-fluoro-5,6-dihydro-6- alkoxy-uracils was synthesised with a modification at the 6-position of the pyrimidine ring. At this position the analogues have a hydroxy or alkoxy group of different chain lengths either in the cis- or trans-configuration. T...

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Detalles Bibliográficos
Autores principales:	van der Wilt, C. L., Visser, G. W., Braakhuis, B. J., Wedzinga, R., Noordhuis, P., Smid, K., Peters, G. J.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1993
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968601/ https://www.ncbi.nlm.nih.gov/pubmed/8398696

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