MDR1 gene expression in primary colorectal carcinomas.

The expression of the MDR1 gene, a multidrug resistance gene, was prospectively determined in 113 primary colorectal carcinoma specimens and correlated with clinical data including survival durations of the patients. MDR1 RNA was detected in 65% of the carcinomas. No expression of the MDR2 gene was...

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Autores principales: Pirker, R., Wallner, J., Gsur, A., Götzl, M., Zöchbauer, S., Scheithauer, W., Depisch, D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968613/
https://www.ncbi.nlm.nih.gov/pubmed/8398695
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author Pirker, R.
Wallner, J.
Gsur, A.
Götzl, M.
Zöchbauer, S.
Scheithauer, W.
Depisch, D.
author_facet Pirker, R.
Wallner, J.
Gsur, A.
Götzl, M.
Zöchbauer, S.
Scheithauer, W.
Depisch, D.
author_sort Pirker, R.
collection PubMed
description The expression of the MDR1 gene, a multidrug resistance gene, was prospectively determined in 113 primary colorectal carcinoma specimens and correlated with clinical data including survival durations of the patients. MDR1 RNA was detected in 65% of the carcinomas. No expression of the MDR2 gene was seen, MDR1 gene expression was independent of age and sex of the patients, size and histologic grading of the tumour, lymph node involvement and distant metastasis. Kaplan-Meier analysis revealed that the durations of both relapse-free survival and overall survival were not different between patients with MDR1 RNA positive tumours and those with MDR1 RNA negative tumours. IMAGES:
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spelling pubmed-19686132009-09-10 MDR1 gene expression in primary colorectal carcinomas. Pirker, R. Wallner, J. Gsur, A. Götzl, M. Zöchbauer, S. Scheithauer, W. Depisch, D. Br J Cancer Research Article The expression of the MDR1 gene, a multidrug resistance gene, was prospectively determined in 113 primary colorectal carcinoma specimens and correlated with clinical data including survival durations of the patients. MDR1 RNA was detected in 65% of the carcinomas. No expression of the MDR2 gene was seen, MDR1 gene expression was independent of age and sex of the patients, size and histologic grading of the tumour, lymph node involvement and distant metastasis. Kaplan-Meier analysis revealed that the durations of both relapse-free survival and overall survival were not different between patients with MDR1 RNA positive tumours and those with MDR1 RNA negative tumours. IMAGES: Nature Publishing Group 1993-10 /pmc/articles/PMC1968613/ /pubmed/8398695 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Pirker, R.
Wallner, J.
Gsur, A.
Götzl, M.
Zöchbauer, S.
Scheithauer, W.
Depisch, D.
MDR1 gene expression in primary colorectal carcinomas.
title MDR1 gene expression in primary colorectal carcinomas.
title_full MDR1 gene expression in primary colorectal carcinomas.
title_fullStr MDR1 gene expression in primary colorectal carcinomas.
title_full_unstemmed MDR1 gene expression in primary colorectal carcinomas.
title_short MDR1 gene expression in primary colorectal carcinomas.
title_sort mdr1 gene expression in primary colorectal carcinomas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968613/
https://www.ncbi.nlm.nih.gov/pubmed/8398695
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