Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer.

A study was made of the incidence of p53 mutations in Japanese males with prostate cancer or benign prostatic hyperplasia. Polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) was used as a primary screening technique with gene sequencing being carried out in positive cases....

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Detalles Bibliográficos
Autores principales: Uchida, T., Wada, C., Shitara, T., Egawa, S., Koshiba, K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968625/
https://www.ncbi.nlm.nih.gov/pubmed/7691145
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author Uchida, T.
Wada, C.
Shitara, T.
Egawa, S.
Koshiba, K.
author_facet Uchida, T.
Wada, C.
Shitara, T.
Egawa, S.
Koshiba, K.
author_sort Uchida, T.
collection PubMed
description A study was made of the incidence of p53 mutations in Japanese males with prostate cancer or benign prostatic hyperplasia. Polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) was used as a primary screening technique with gene sequencing being carried out in positive cases. Two out of 21 prostate cancers (9.5%) were found to have p53 mutations. These were stage B2 and D2 prostate cancers. No abnormalities were found in the remaining cases or benign prostatic hyperplasia. Mutations of the p53 gene would thus appear infrequent in the tumourigenesis of primary prostate cancer. IMAGES:
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spelling pubmed-19686252009-09-10 Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer. Uchida, T. Wada, C. Shitara, T. Egawa, S. Koshiba, K. Br J Cancer Research Article A study was made of the incidence of p53 mutations in Japanese males with prostate cancer or benign prostatic hyperplasia. Polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) was used as a primary screening technique with gene sequencing being carried out in positive cases. Two out of 21 prostate cancers (9.5%) were found to have p53 mutations. These were stage B2 and D2 prostate cancers. No abnormalities were found in the remaining cases or benign prostatic hyperplasia. Mutations of the p53 gene would thus appear infrequent in the tumourigenesis of primary prostate cancer. IMAGES: Nature Publishing Group 1993-10 /pmc/articles/PMC1968625/ /pubmed/7691145 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Uchida, T.
Wada, C.
Shitara, T.
Egawa, S.
Koshiba, K.
Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer.
title Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer.
title_full Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer.
title_fullStr Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer.
title_full_unstemmed Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer.
title_short Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer.
title_sort infrequent involvement of p53 gene mutations in the tumourigenesis of japanese prostate cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968625/
https://www.ncbi.nlm.nih.gov/pubmed/7691145
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