Cargando…

Expression of MDR1/P glycoprotein in human sarcomas.

Conflicting reports of MDR1 gene expression in human tumours are observed according to whether studies are performed at the mRNA or P-glycoprotein level. We have investigated this expression in 22 clinically drug-resistant sarcomas at the mRNA level by Northern blot (NB), Dot blot (DB), in situ hybr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vergier, B., Cany, L., Bonnet, F., Robert, J., de Mascarel, A., Coindre, J. M.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1993
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968648/ https://www.ncbi.nlm.nih.gov/pubmed/7903154

Ejemplares similares

Raltegravir does not revert efflux activity of MDR1-P-glycoprotein in human MDR cells
por: Dupuis, Maria Luisa, et al.
Publicado: (2013)

Catalytic Transitions in the Human MDR1 P-Glycoprotein Drug Binding Sites
por: Wise, John G.
Publicado: (2012)

Influence of RARα gene on MDR1 expression and P-glycoprotein function in human leukemic cells
por: Stromskaya, Tatjana P, et al.
Publicado: (2005)

mdm2 gene mediates the expression of mdr1 gene and P-glycoprotein in a human glioblastoma cell line.
por: Kondo, S., et al.
Publicado: (1996)

P-Glycoprotein/MDR1 Regulates Pokemon Gene Transcription Through p53 Expression in Human Breast Cancer Cells
por: He, Shengnan, et al.
Publicado: (2010)

Primary chemotherapy in breast invasive carcinoma: predictive value of the immunohistochemical detection of hormonal receptors, p53, c-erbB-2, MiB1, pS2 and GST pi.
por: MacGrogan, G., et al.
Publicado: (1996)

Validation of a P-Glycoprotein (P-gp) Humanized Mouse Model by Integrating Selective Absolute Quantification of Human MDR1, Mouse Mdr1a and Mdr1b Protein Expressions with In Vivo Functional Analysis for Blood-Brain Barrier Transport
por: Sadiq, Muhammad Waqas, et al.
Publicado: (2015)

Influence of exogenous RAR alpha gene on MDR1 expression and P-glycoprotein function in human and rodent cell lines.
por: Stromskaya, T. P., et al.
Publicado: (1998)

Micrometastases to axillary lymph nodes from invasive lobular carcinoma of breast: detection by immunohistochemistry and prognostic significance.
por: Trojani, M., et al.
Publicado: (1987)

Prognostic significance of breast cancer axillary lymph node micrometastases assessed by two special techniques: reevaluation with longer follow-up.
por: de Mascarel, I., et al.
Publicado: (1992)

Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells
por: Ding, Zhenyu, et al.
Publicado: (2010)

Association between MDR1 gene of gastrointestinal tumors, the expression of P-glycoprotein and resistance to chemotherapeutic drugs
por: Su, Jian-Li, et al.
Publicado: (2017)

Emodin alleviates gemcitabine resistance in pancreatic cancer by inhibiting MDR1/P-glycoprotein and MRPs expression
por: Guo, Hongchun, et al.
Publicado: (2020)

HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein
por: Cianfriglia, Maurizio, et al.
Publicado: (2007)

Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice
por: Brenn, Anja, et al.
Publicado: (2011)

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein
por: Asperen, J van, et al.
Publicado: (1999)

Relationship between the expression of cyclooxygenase 2 and MDR1/P-glycoprotein in invasive breast cancers and their prognostic significance
por: Surowiak, Pawel, et al.
Publicado: (2005)

Inhibitory Effects of Neochamaejasmin B on P-Glycoprotein in MDCK-hMDR1 Cells and Molecular Docking of NCB Binding in P-Glycoprotein
por: Pan, Lanying, et al.
Publicado: (2015)

Micrometastases to axillary lymph nodes from carcinoma of breast: detection by immunohistochemistry and prognostic significance.
por: Trojani, M., et al.
Publicado: (1987)

Association between 8 P‐glycoprotein (MDR1/ABCB1) gene polymorphisms and antipsychotic drug‐induced hyperprolactinaemia
por: Geers, Lisanne M., et al.
Publicado: (2020)

IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes
por: Saaby, Lasse, et al.
Publicado: (2020)

Mdr1/P-glycoprotein, topoisomerase, and glutathione-S-transferase pi gene expression in primary and relapsed state adult and childhood leukaemias.
por: Gekeler, V., et al.
Publicado: (1992)

Selective inhibition of MDR1 P-glycoprotein-mediated transport by the acridone carboxamide derivative GG918
por: Wallstab, A, et al.
Publicado: (1999)

Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA
por: Pluchino, Kristen M., et al.
Publicado: (2015)

Quantitative Structure–Activity Relationships for the Flavonoid-Mediated Inhibition of P-Glycoprotein in KB/MDR1 Cells
por: Xia, Mengmeng, et al.
Publicado: (2019)

Exposure to HIV-protease inhibitors selects for increased expression of P-glycoprotein (ABCB1) in Kaposi's sarcoma cells
por: Lucia, M B, et al.
Publicado: (2011)

Expression and significance of hypoxia-inducible factor-1α and MDR1/P-glycoprotein in laryngeal carcinoma tissue and hypoxic Hep-2 cells
por: XIE, JIN, et al.
Publicado: (2013)

Anlotinib Reverses Multidrug Resistance (MDR) in Osteosarcoma by Inhibiting P-Glycoprotein (PGP1) Function In Vitro and In Vivo
por: Wang, Gangyang, et al.
Publicado: (2022)

Non-Nutritive Sweeteners Acesulfame Potassium and Sucralose Are Competitive Inhibitors of the Human P-glycoprotein/Multidrug Resistance Protein 1 (PGP/MDR1)
por: Danner, Laura, et al.
Publicado: (2023)

HIF-1α Inhibition Reverses Multidrug Resistance in Colon Cancer Cells via Downregulation of MDR1/P-Glycoprotein
por: Chen, Jianfang, et al.
Publicado: (2014)

High MDR‐1 expression by MAIT cells confers resistance to cytotoxic but not immunosuppressive MDR‐1 substrates
por: Fergusson, J.R., et al.
Publicado: (2018)

Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines
por: Gericke, Birthe, et al.
Publicado: (2021)

TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3β pathway and activation of caspases
por: Seo, Suk-Bin, et al.
Publicado: (2010)

P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain
por: Porteous, Carolyn M., et al.
Publicado: (2013)

New Dual P-Glycoprotein (P-gp) and Human Carbonic Anhydrase XII (hCA XII) Inhibitors as Multidrug Resistance (MDR) Reversers in Cancer Cells
por: Braconi, Laura, et al.
Publicado: (2022)

DNA topoisomerase IIα expression and the response toprimary chemotherapy in breast cancer
por: MacGrogan, G, et al.
Publicado: (2003)

MDR1 gene expression in primary colorectal carcinomas.
por: Pirker, R., et al.
Publicado: (1993)

Cepharanthine hydrochloride reverses the mdr1 (P-glycoprotein)-mediated esophageal squamous cell carcinoma cell cisplatin resistance through JNK and p53 signals
por: Zhou, Pengjun, et al.
Publicado: (2017)

SMYD2-OE promotes oxaliplatin resistance in colon cancer through MDR1/P-glycoprotein via MEK/ERK/AP1 pathway
por: Ren, Hailiang, et al.
Publicado: (2019)

The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1
por: Saaby, Lasse, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_us9vtq99mla1kail8bd4rp3j3a