Increase in mast cells and hyaluronic acid correlates to radiation-induced damage and loss of serous acinar cells in salivary glands: the parotid and submandibular glands differ in radiation sensitivity.

The detailed mechanisms which can explain the inherent radiosensitivity of salivary glands remain to be elucidated. Although DNA is the most plausible critical target for the lethal effects of irradiation, interactions with other constituents, such as cell membrane and neuropeptides, have been sugge...

Descripción completa

Detalles Bibliográficos
Autores principales: Henriksson, R., Fröjd, O., Gustafsson, H., Johansson, S., Yi-Qing, C., Franzén, L., Bjermer, L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968701/
https://www.ncbi.nlm.nih.gov/pubmed/8297728
_version_ 1782134797956546560
author Henriksson, R.
Fröjd, O.
Gustafsson, H.
Johansson, S.
Yi-Qing, C.
Franzén, L.
Bjermer, L.
author_facet Henriksson, R.
Fröjd, O.
Gustafsson, H.
Johansson, S.
Yi-Qing, C.
Franzén, L.
Bjermer, L.
author_sort Henriksson, R.
collection PubMed
description The detailed mechanisms which can explain the inherent radiosensitivity of salivary glands remain to be elucidated. Although DNA is the most plausible critical target for the lethal effects of irradiation, interactions with other constituents, such as cell membrane and neuropeptides, have been suggested to cause important physiological changes. Moreover, mast cells seem to be closely linked to radiation-induced pneumonitis. Therefore, in the present study the effects of fractionated irradiation on salivary glands have been assessed with special regard to the appearance of mast cells and its correlation with damage to gland parenchyma. Sprague-Dawley strain rats were unilaterally irradiated to the head and neck with the salivary glands within the radiation field. The irradiation was delivered once daily for 5 days to a total dose of 20, 35 and 45 Gy. The contralateral parotid and submandibular glands served as intra-animal controls and parallel analysis of glands was performed 2, 4, 10 or 180 days following the last radiation treatment. Morphological analysis revealed no obvious changes up to 10 days after the irradiation. At 180 days a radiation dose-dependent loss of gland parenchyma was seen, especially with regard to serious acinar cells in parotid gland and acinar cells and serous CGT (convoluted granular tubule) cells in the submandibular gland. These changes displayed a close correlation with a concomitant dose-dependent enhanced density of mast cells and staining for hyaluronic acid. This cell population seems to conform with the features of the connective tissue mast cell type. The parotid seems to be more sensitive to irradiation than the submandibular gland. Thus, the present results further strengthen the role of and the potential interaction of mast cells with radiation-induced tissue injury and alterations in normal tissue integrity. IMAGES:
format Text
id pubmed-1968701
institution National Center for Biotechnology Information
language English
publishDate 1994
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-19687012009-09-10 Increase in mast cells and hyaluronic acid correlates to radiation-induced damage and loss of serous acinar cells in salivary glands: the parotid and submandibular glands differ in radiation sensitivity. Henriksson, R. Fröjd, O. Gustafsson, H. Johansson, S. Yi-Qing, C. Franzén, L. Bjermer, L. Br J Cancer Research Article The detailed mechanisms which can explain the inherent radiosensitivity of salivary glands remain to be elucidated. Although DNA is the most plausible critical target for the lethal effects of irradiation, interactions with other constituents, such as cell membrane and neuropeptides, have been suggested to cause important physiological changes. Moreover, mast cells seem to be closely linked to radiation-induced pneumonitis. Therefore, in the present study the effects of fractionated irradiation on salivary glands have been assessed with special regard to the appearance of mast cells and its correlation with damage to gland parenchyma. Sprague-Dawley strain rats were unilaterally irradiated to the head and neck with the salivary glands within the radiation field. The irradiation was delivered once daily for 5 days to a total dose of 20, 35 and 45 Gy. The contralateral parotid and submandibular glands served as intra-animal controls and parallel analysis of glands was performed 2, 4, 10 or 180 days following the last radiation treatment. Morphological analysis revealed no obvious changes up to 10 days after the irradiation. At 180 days a radiation dose-dependent loss of gland parenchyma was seen, especially with regard to serious acinar cells in parotid gland and acinar cells and serous CGT (convoluted granular tubule) cells in the submandibular gland. These changes displayed a close correlation with a concomitant dose-dependent enhanced density of mast cells and staining for hyaluronic acid. This cell population seems to conform with the features of the connective tissue mast cell type. The parotid seems to be more sensitive to irradiation than the submandibular gland. Thus, the present results further strengthen the role of and the potential interaction of mast cells with radiation-induced tissue injury and alterations in normal tissue integrity. IMAGES: Nature Publishing Group 1994-02 /pmc/articles/PMC1968701/ /pubmed/8297728 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Henriksson, R.
Fröjd, O.
Gustafsson, H.
Johansson, S.
Yi-Qing, C.
Franzén, L.
Bjermer, L.
Increase in mast cells and hyaluronic acid correlates to radiation-induced damage and loss of serous acinar cells in salivary glands: the parotid and submandibular glands differ in radiation sensitivity.
title Increase in mast cells and hyaluronic acid correlates to radiation-induced damage and loss of serous acinar cells in salivary glands: the parotid and submandibular glands differ in radiation sensitivity.
title_full Increase in mast cells and hyaluronic acid correlates to radiation-induced damage and loss of serous acinar cells in salivary glands: the parotid and submandibular glands differ in radiation sensitivity.
title_fullStr Increase in mast cells and hyaluronic acid correlates to radiation-induced damage and loss of serous acinar cells in salivary glands: the parotid and submandibular glands differ in radiation sensitivity.
title_full_unstemmed Increase in mast cells and hyaluronic acid correlates to radiation-induced damage and loss of serous acinar cells in salivary glands: the parotid and submandibular glands differ in radiation sensitivity.
title_short Increase in mast cells and hyaluronic acid correlates to radiation-induced damage and loss of serous acinar cells in salivary glands: the parotid and submandibular glands differ in radiation sensitivity.
title_sort increase in mast cells and hyaluronic acid correlates to radiation-induced damage and loss of serous acinar cells in salivary glands: the parotid and submandibular glands differ in radiation sensitivity.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968701/
https://www.ncbi.nlm.nih.gov/pubmed/8297728
work_keys_str_mv AT henrikssonr increaseinmastcellsandhyaluronicacidcorrelatestoradiationinduceddamageandlossofserousacinarcellsinsalivaryglandstheparotidandsubmandibularglandsdifferinradiationsensitivity
AT frojdo increaseinmastcellsandhyaluronicacidcorrelatestoradiationinduceddamageandlossofserousacinarcellsinsalivaryglandstheparotidandsubmandibularglandsdifferinradiationsensitivity
AT gustafssonh increaseinmastcellsandhyaluronicacidcorrelatestoradiationinduceddamageandlossofserousacinarcellsinsalivaryglandstheparotidandsubmandibularglandsdifferinradiationsensitivity
AT johanssons increaseinmastcellsandhyaluronicacidcorrelatestoradiationinduceddamageandlossofserousacinarcellsinsalivaryglandstheparotidandsubmandibularglandsdifferinradiationsensitivity
AT yiqingc increaseinmastcellsandhyaluronicacidcorrelatestoradiationinduceddamageandlossofserousacinarcellsinsalivaryglandstheparotidandsubmandibularglandsdifferinradiationsensitivity
AT franzenl increaseinmastcellsandhyaluronicacidcorrelatestoradiationinduceddamageandlossofserousacinarcellsinsalivaryglandstheparotidandsubmandibularglandsdifferinradiationsensitivity
AT bjermerl increaseinmastcellsandhyaluronicacidcorrelatestoradiationinduceddamageandlossofserousacinarcellsinsalivaryglandstheparotidandsubmandibularglandsdifferinradiationsensitivity

Ejemplares similares