Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517).

Human colon adenocarcinoma cells (LoVo) resistant to the new antitumor agent FCE 24517 [benzoyl-mustard derivative of distamycin A] (LoVo/24517) are resistant to the selecting agent and related molecules as well as to vinblastine, with marginal or no resistance to other antitumour drugs. Treatment w...

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Detalles Bibliográficos
Autores principales: Capolongo, L., Melegaro, G., Broggini, M., Mongelli, N., Grandi, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1993
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968750/
https://www.ncbi.nlm.nih.gov/pubmed/8105866
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author Capolongo, L.
Melegaro, G.
Broggini, M.
Mongelli, N.
Grandi, M.
author_facet Capolongo, L.
Melegaro, G.
Broggini, M.
Mongelli, N.
Grandi, M.
author_sort Capolongo, L.
collection PubMed
description Human colon adenocarcinoma cells (LoVo) resistant to the new antitumor agent FCE 24517 [benzoyl-mustard derivative of distamycin A] (LoVo/24517) are resistant to the selecting agent and related molecules as well as to vinblastine, with marginal or no resistance to other antitumour drugs. Treatment with verapamil, tamoxifen, nicergoline or cyclosporin A only partially restores the activity of FCE 24517 against LoVo/24517 cells. Such results suggest that resistance mechanisms possible specific for this class of compounds are operating. IMAGES:
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spelling pubmed-19687502009-09-10 Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517). Capolongo, L. Melegaro, G. Broggini, M. Mongelli, N. Grandi, M. Br J Cancer Research Article Human colon adenocarcinoma cells (LoVo) resistant to the new antitumor agent FCE 24517 [benzoyl-mustard derivative of distamycin A] (LoVo/24517) are resistant to the selecting agent and related molecules as well as to vinblastine, with marginal or no resistance to other antitumour drugs. Treatment with verapamil, tamoxifen, nicergoline or cyclosporin A only partially restores the activity of FCE 24517 against LoVo/24517 cells. Such results suggest that resistance mechanisms possible specific for this class of compounds are operating. IMAGES: Nature Publishing Group 1993-11 /pmc/articles/PMC1968750/ /pubmed/8105866 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Capolongo, L.
Melegaro, G.
Broggini, M.
Mongelli, N.
Grandi, M.
Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517).
title Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517).
title_full Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517).
title_fullStr Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517).
title_full_unstemmed Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517).
title_short Characterisation of a LoVo subline resistant to a benzoyl mustard derivative of distamycin A (FCE 24517).
title_sort characterisation of a lovo subline resistant to a benzoyl mustard derivative of distamycin a (fce 24517).
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968750/
https://www.ncbi.nlm.nih.gov/pubmed/8105866
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