Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast.

Glutathione S-transferase Pi (GST P) has been reported to be a marker of dysplastic lesions. For this reason expression of GST P by intraduct breast carcinoma was evaluated by immunohistochemistry. Thirty-seven of 92 carcinomas (40%) were GST P positive. GST P staining did not correlate with histolo...

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Detalles Bibliográficos
Autores principales: Bellamy, C. O., Harrison, D. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968756/
https://www.ncbi.nlm.nih.gov/pubmed/7904475
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author Bellamy, C. O.
Harrison, D. J.
author_facet Bellamy, C. O.
Harrison, D. J.
author_sort Bellamy, C. O.
collection PubMed
description Glutathione S-transferase Pi (GST P) has been reported to be a marker of dysplastic lesions. For this reason expression of GST P by intraduct breast carcinoma was evaluated by immunohistochemistry. Thirty-seven of 92 carcinomas (40%) were GST P positive. GST P staining did not correlate with histological variables, c-erbB-2 overexpression or with clinical outcome. The GST P status of recurrences did not correlate with that of the index lesion. There is little evidence that GST P is a useful marker of the potential of intraduct breast carcinoma to become invasive. IMAGES:
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spelling pubmed-19687562009-09-10 Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast. Bellamy, C. O. Harrison, D. J. Br J Cancer Research Article Glutathione S-transferase Pi (GST P) has been reported to be a marker of dysplastic lesions. For this reason expression of GST P by intraduct breast carcinoma was evaluated by immunohistochemistry. Thirty-seven of 92 carcinomas (40%) were GST P positive. GST P staining did not correlate with histological variables, c-erbB-2 overexpression or with clinical outcome. The GST P status of recurrences did not correlate with that of the index lesion. There is little evidence that GST P is a useful marker of the potential of intraduct breast carcinoma to become invasive. IMAGES: Nature Publishing Group 1994-01 /pmc/articles/PMC1968756/ /pubmed/7904475 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Bellamy, C. O.
Harrison, D. J.
Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast.
title Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast.
title_full Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast.
title_fullStr Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast.
title_full_unstemmed Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast.
title_short Evaluation of glutathione S-transferase Pi in non-invasive ductal carcinoma of breast.
title_sort evaluation of glutathione s-transferase pi in non-invasive ductal carcinoma of breast.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968756/
https://www.ncbi.nlm.nih.gov/pubmed/7904475
work_keys_str_mv AT bellamyco evaluationofglutathionestransferasepiinnoninvasiveductalcarcinomaofbreast
AT harrisondj evaluationofglutathionestransferasepiinnoninvasiveductalcarcinomaofbreast

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