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Duck hepatitis B virus infection, aflatoxin B1 and liver cancer in domestic Chinese ducks.

The oncogenicity of Duck hepatitis B virus (DHBV) is unclear since hepatocellular carcinomas (HCCs) have been reported only in domestic ducks in Qidong, an area of China where hepatitis B virus (HBV) and aflatoxin B1 (AFB1) are risk factors for liver cancer in man. In order to better define the asso...

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Autores principales: Cova, L., Mehrotra, R., Wild, C. P., Chutimataewin, S., Cao, S. F., Duflot, A., Prave, M., Yu, S. Z., Montesano, R., Trepo, C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968768/
https://www.ncbi.nlm.nih.gov/pubmed/8286190
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author Cova, L.
Mehrotra, R.
Wild, C. P.
Chutimataewin, S.
Cao, S. F.
Duflot, A.
Prave, M.
Yu, S. Z.
Montesano, R.
Trepo, C.
author_facet Cova, L.
Mehrotra, R.
Wild, C. P.
Chutimataewin, S.
Cao, S. F.
Duflot, A.
Prave, M.
Yu, S. Z.
Montesano, R.
Trepo, C.
author_sort Cova, L.
collection PubMed
description The oncogenicity of Duck hepatitis B virus (DHBV) is unclear since hepatocellular carcinomas (HCCs) have been reported only in domestic ducks in Qidong, an area of China where hepatitis B virus (HBV) and aflatoxin B1 (AFB1) are risk factors for liver cancer in man. In order to better define the association between DHBV infection, AFB1 and HCC we analysed a series of 16 duck liver samples collected from local farms in Qidong. HCC was found in eight and cirrhosis in one of these samples. Furthermore bile duct proliferation, characteristic of AFB1 exposure in ducks and other animal species, was found in these ducks. Integration of DHBV DNA into cellular DNA was observed in only one out of four DHBV positive HCCs, indicating that viral integration is not prerequisite for tumour development. In four remaining HCCs the polymerase chain reaction (PCR) failed to show any DHBV DNA suggesting that liver tumours do occur in polymerase chain reaction (PCR) failed to show any DHBV DNA suggesting that liver tumours do occur in these ducks in the absence of DHBV infection. In addition, AFB1-DNA adducts were detected by hplc-immunoassay in one such DHBV-negative tumour. In summary we demonstrate that risk factors other than DHBV, including AFB1 exposure, may be important in duck liver carcinogenesis in Qidong. IMAGES:
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spelling pubmed-19687682009-09-10 Duck hepatitis B virus infection, aflatoxin B1 and liver cancer in domestic Chinese ducks. Cova, L. Mehrotra, R. Wild, C. P. Chutimataewin, S. Cao, S. F. Duflot, A. Prave, M. Yu, S. Z. Montesano, R. Trepo, C. Br J Cancer Research Article The oncogenicity of Duck hepatitis B virus (DHBV) is unclear since hepatocellular carcinomas (HCCs) have been reported only in domestic ducks in Qidong, an area of China where hepatitis B virus (HBV) and aflatoxin B1 (AFB1) are risk factors for liver cancer in man. In order to better define the association between DHBV infection, AFB1 and HCC we analysed a series of 16 duck liver samples collected from local farms in Qidong. HCC was found in eight and cirrhosis in one of these samples. Furthermore bile duct proliferation, characteristic of AFB1 exposure in ducks and other animal species, was found in these ducks. Integration of DHBV DNA into cellular DNA was observed in only one out of four DHBV positive HCCs, indicating that viral integration is not prerequisite for tumour development. In four remaining HCCs the polymerase chain reaction (PCR) failed to show any DHBV DNA suggesting that liver tumours do occur in polymerase chain reaction (PCR) failed to show any DHBV DNA suggesting that liver tumours do occur in these ducks in the absence of DHBV infection. In addition, AFB1-DNA adducts were detected by hplc-immunoassay in one such DHBV-negative tumour. In summary we demonstrate that risk factors other than DHBV, including AFB1 exposure, may be important in duck liver carcinogenesis in Qidong. IMAGES: Nature Publishing Group 1994-01 /pmc/articles/PMC1968768/ /pubmed/8286190 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Cova, L.
Mehrotra, R.
Wild, C. P.
Chutimataewin, S.
Cao, S. F.
Duflot, A.
Prave, M.
Yu, S. Z.
Montesano, R.
Trepo, C.
Duck hepatitis B virus infection, aflatoxin B1 and liver cancer in domestic Chinese ducks.
title Duck hepatitis B virus infection, aflatoxin B1 and liver cancer in domestic Chinese ducks.
title_full Duck hepatitis B virus infection, aflatoxin B1 and liver cancer in domestic Chinese ducks.
title_fullStr Duck hepatitis B virus infection, aflatoxin B1 and liver cancer in domestic Chinese ducks.
title_full_unstemmed Duck hepatitis B virus infection, aflatoxin B1 and liver cancer in domestic Chinese ducks.
title_short Duck hepatitis B virus infection, aflatoxin B1 and liver cancer in domestic Chinese ducks.
title_sort duck hepatitis b virus infection, aflatoxin b1 and liver cancer in domestic chinese ducks.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968768/
https://www.ncbi.nlm.nih.gov/pubmed/8286190
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