E-cadherin expression in basal cell carcinoma.

E-cadherin (E-CD) is a calcium-dependent cell-cell adhesion molecule which is expressed in almost all epithelial tissues. E-CD expression is involved in epidermal morphogenesis and is reduced during tumour progression of mouse epidermal carcinogenesis. It has been suggested that E-CD could play a ro...

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Autores principales: Pizarro, A., Benito, N., Navarro, P., Palacios, J., Cano, A., Quintanilla, M., Contreras, F., Gamallo, C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968779/
https://www.ncbi.nlm.nih.gov/pubmed/8286199
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author Pizarro, A.
Benito, N.
Navarro, P.
Palacios, J.
Cano, A.
Quintanilla, M.
Contreras, F.
Gamallo, C.
author_facet Pizarro, A.
Benito, N.
Navarro, P.
Palacios, J.
Cano, A.
Quintanilla, M.
Contreras, F.
Gamallo, C.
author_sort Pizarro, A.
collection PubMed
description E-cadherin (E-CD) is a calcium-dependent cell-cell adhesion molecule which is expressed in almost all epithelial tissues. E-CD expression is involved in epidermal morphogenesis and is reduced during tumour progression of mouse epidermal carcinogenesis. It has been suggested that E-CD could play a role as an invasion-suppressor molecule. In the present work we have studied the E-CD expression in 31 patients with basal cell carcinoma (BCC) using an immunohistochemical technique with a monoclonal antibody (HECD-1) specific for human E-CD. E-CD expression was preserved in all specimens of superficial and nodular BCC, and was reduced in 10 of 15 infiltrative BCCs. A heterogeneous distribution of cells with different immunostaining intensity was more frequently observed in specimens of infiltrative BCC. These results suggest that E-CD might be related to the growth pattern and the local aggressive behaviour of BCC, and support the idea that E-CD might play a role as an invasion-suppressor molecule in vivo. IMAGES:
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spelling pubmed-19687792009-09-10 E-cadherin expression in basal cell carcinoma. Pizarro, A. Benito, N. Navarro, P. Palacios, J. Cano, A. Quintanilla, M. Contreras, F. Gamallo, C. Br J Cancer Research Article E-cadherin (E-CD) is a calcium-dependent cell-cell adhesion molecule which is expressed in almost all epithelial tissues. E-CD expression is involved in epidermal morphogenesis and is reduced during tumour progression of mouse epidermal carcinogenesis. It has been suggested that E-CD could play a role as an invasion-suppressor molecule. In the present work we have studied the E-CD expression in 31 patients with basal cell carcinoma (BCC) using an immunohistochemical technique with a monoclonal antibody (HECD-1) specific for human E-CD. E-CD expression was preserved in all specimens of superficial and nodular BCC, and was reduced in 10 of 15 infiltrative BCCs. A heterogeneous distribution of cells with different immunostaining intensity was more frequently observed in specimens of infiltrative BCC. These results suggest that E-CD might be related to the growth pattern and the local aggressive behaviour of BCC, and support the idea that E-CD might play a role as an invasion-suppressor molecule in vivo. IMAGES: Nature Publishing Group 1994-01 /pmc/articles/PMC1968779/ /pubmed/8286199 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Pizarro, A.
Benito, N.
Navarro, P.
Palacios, J.
Cano, A.
Quintanilla, M.
Contreras, F.
Gamallo, C.
E-cadherin expression in basal cell carcinoma.
title E-cadherin expression in basal cell carcinoma.
title_full E-cadherin expression in basal cell carcinoma.
title_fullStr E-cadherin expression in basal cell carcinoma.
title_full_unstemmed E-cadherin expression in basal cell carcinoma.
title_short E-cadherin expression in basal cell carcinoma.
title_sort e-cadherin expression in basal cell carcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968779/
https://www.ncbi.nlm.nih.gov/pubmed/8286199
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