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Altered stability of etoposide-induced topoisomerase II-DNA complexes in resistant human leukaemia K562 cells.

K562 leukaemia cells were selected for resistance using 0.5 microM etoposide (VP-16). Cloned K/VP.5 cells were 30-fold resistant to growth inhibition by VP-16 and 5- to 13-fold resistant to m-AMSA, adriamycin and mitoxantrone. K/VP.5 cells did not overexpress P-glycoprotein; VP-16 accumulation was s...

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Detalles Bibliográficos
Autores principales:	Ritke, M. K., Roberts, D., Allan, W. P., Raymond, J., Bergoltz, V. V., Yalowich, J. C.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1994
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968798/ https://www.ncbi.nlm.nih.gov/pubmed/8142256

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