The effect of cryotherapy on the cremaster muscle microcirculation in vivo.

The effect of cryotherapy on normal striated muscle was investigated using 18 adult male rats. Animals were divided into two groups, an experimental cryotherapy group and a control group receiving sham treatment. After the surgical procedure animals were allowed to equilibrate and vessel diameters,...

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Detalles Bibliográficos
Autores principales: Brown, N. J., Pollock, K. J., Bayjoo, P., Reed, M. W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968805/
https://www.ncbi.nlm.nih.gov/pubmed/8142258
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author Brown, N. J.
Pollock, K. J.
Bayjoo, P.
Reed, M. W.
author_facet Brown, N. J.
Pollock, K. J.
Bayjoo, P.
Reed, M. W.
author_sort Brown, N. J.
collection PubMed
description The effect of cryotherapy on normal striated muscle was investigated using 18 adult male rats. Animals were divided into two groups, an experimental cryotherapy group and a control group receiving sham treatment. After the surgical procedure animals were allowed to equilibrate and vessel diameters, macromolecular leakage and blood flow were assessed before the cremaster muscle was frozen to -60 degrees C. After thawing measurements were taken every 15 min over a 2 h period. Cryotherapy resulted in an initial reduction in blood flow followed by a brief period of reperfusion, with complete vascular stasis eventually observed. Macromolecular leakage occurred from all vessels, which mirrored the fluctuations in blood flow. Transient changes in vessel diameters were also observed. Histology confirmed the in vivo observations of vessel congestion and muscle damage. The data suggest that cessation of flow and increased macromolecular leakage within the muscle may contribute to the cell death and tumour necrosis observed following cryotherapy. IMAGES:
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spelling pubmed-19688052009-09-10 The effect of cryotherapy on the cremaster muscle microcirculation in vivo. Brown, N. J. Pollock, K. J. Bayjoo, P. Reed, M. W. Br J Cancer Research Article The effect of cryotherapy on normal striated muscle was investigated using 18 adult male rats. Animals were divided into two groups, an experimental cryotherapy group and a control group receiving sham treatment. After the surgical procedure animals were allowed to equilibrate and vessel diameters, macromolecular leakage and blood flow were assessed before the cremaster muscle was frozen to -60 degrees C. After thawing measurements were taken every 15 min over a 2 h period. Cryotherapy resulted in an initial reduction in blood flow followed by a brief period of reperfusion, with complete vascular stasis eventually observed. Macromolecular leakage occurred from all vessels, which mirrored the fluctuations in blood flow. Transient changes in vessel diameters were also observed. Histology confirmed the in vivo observations of vessel congestion and muscle damage. The data suggest that cessation of flow and increased macromolecular leakage within the muscle may contribute to the cell death and tumour necrosis observed following cryotherapy. IMAGES: Nature Publishing Group 1994-04 /pmc/articles/PMC1968805/ /pubmed/8142258 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Brown, N. J.
Pollock, K. J.
Bayjoo, P.
Reed, M. W.
The effect of cryotherapy on the cremaster muscle microcirculation in vivo.
title The effect of cryotherapy on the cremaster muscle microcirculation in vivo.
title_full The effect of cryotherapy on the cremaster muscle microcirculation in vivo.
title_fullStr The effect of cryotherapy on the cremaster muscle microcirculation in vivo.
title_full_unstemmed The effect of cryotherapy on the cremaster muscle microcirculation in vivo.
title_short The effect of cryotherapy on the cremaster muscle microcirculation in vivo.
title_sort effect of cryotherapy on the cremaster muscle microcirculation in vivo.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968805/
https://www.ncbi.nlm.nih.gov/pubmed/8142258
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