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Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma.

Proliferative activities in 181 primary Borrmann type 4 gastric carcinomas were investigated using percentage labelling of proliferating cell nuclear antigen (PCNA) and an argyrophilic nucleolar organiser region (AgNOR) count. Tumours with a high proliferative activity often metastasised to lymph no...

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Autores principales: Kakeji, Y., Maehara, Y., Adachi, Y., Baba, H., Mori, M., Furusawa, M., Sugimachi, K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968815/
https://www.ncbi.nlm.nih.gov/pubmed/7908217
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author Kakeji, Y.
Maehara, Y.
Adachi, Y.
Baba, H.
Mori, M.
Furusawa, M.
Sugimachi, K.
author_facet Kakeji, Y.
Maehara, Y.
Adachi, Y.
Baba, H.
Mori, M.
Furusawa, M.
Sugimachi, K.
author_sort Kakeji, Y.
collection PubMed
description Proliferative activities in 181 primary Borrmann type 4 gastric carcinomas were investigated using percentage labelling of proliferating cell nuclear antigen (PCNA) and an argyrophilic nucleolar organiser region (AgNOR) count. Tumours with a high proliferative activity often metastasised to lymph nodes (P < 0.01), and these patients had a lower survival rate (P < 0.05). A significant correlation was recognised between the PCNA labelling percentage and AgNOR count (r = 0.452, P < 0.001). Cox's regression analysis showed that PCNA labelling percentage is an independent prognostic factor. These results indicate that estimating proliferative activity may be useful in predicting lymph node metastasis and patients' prognosis in cases of Borrmann type 4 gastric carcinoma. IMAGES:
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spelling pubmed-19688152009-09-10 Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma. Kakeji, Y. Maehara, Y. Adachi, Y. Baba, H. Mori, M. Furusawa, M. Sugimachi, K. Br J Cancer Research Article Proliferative activities in 181 primary Borrmann type 4 gastric carcinomas were investigated using percentage labelling of proliferating cell nuclear antigen (PCNA) and an argyrophilic nucleolar organiser region (AgNOR) count. Tumours with a high proliferative activity often metastasised to lymph nodes (P < 0.01), and these patients had a lower survival rate (P < 0.05). A significant correlation was recognised between the PCNA labelling percentage and AgNOR count (r = 0.452, P < 0.001). Cox's regression analysis showed that PCNA labelling percentage is an independent prognostic factor. These results indicate that estimating proliferative activity may be useful in predicting lymph node metastasis and patients' prognosis in cases of Borrmann type 4 gastric carcinoma. IMAGES: Nature Publishing Group 1994-04 /pmc/articles/PMC1968815/ /pubmed/7908217 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Kakeji, Y.
Maehara, Y.
Adachi, Y.
Baba, H.
Mori, M.
Furusawa, M.
Sugimachi, K.
Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma.
title Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma.
title_full Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma.
title_fullStr Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma.
title_full_unstemmed Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma.
title_short Proliferative activity as a prognostic factor in Borrmann type 4 gastric carcinoma.
title_sort proliferative activity as a prognostic factor in borrmann type 4 gastric carcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968815/
https://www.ncbi.nlm.nih.gov/pubmed/7908217
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