Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease.

The messenger RNAs for the angiogenic acidic and basic fibroblast growth factors are expressed at a significantly higher level in samples of human benign neoplastic and hyperplastic tissue than in samples from breast cancers. However, approximately one in four malignant breast cancer samples contain...

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Autores principales: Anandappa, S. Y., Winstanley, J. H., Leinster, S., Green, B., Rudland, P. S., Barraclough, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968831/
https://www.ncbi.nlm.nih.gov/pubmed/7511406
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author Anandappa, S. Y.
Winstanley, J. H.
Leinster, S.
Green, B.
Rudland, P. S.
Barraclough, R.
author_facet Anandappa, S. Y.
Winstanley, J. H.
Leinster, S.
Green, B.
Rudland, P. S.
Barraclough, R.
author_sort Anandappa, S. Y.
collection PubMed
description The messenger RNAs for the angiogenic acidic and basic fibroblast growth factors are expressed at a significantly higher level in samples of human benign neoplastic and hyperplastic tissue than in samples from breast cancers. However, approximately one in four malignant breast cancer samples contain basic fibroblast growth factor mRNA at the same level as in the benign lesions when basic fibroblast growth factor mRNA levels are corrected with respect to levels of expression of glyceraldehyde-3-phosphate dehydrogenase mRNA. A similar proportion of human malignant breast cancer cell lines express a high level of basic fibroblast growth factor mRNA. The results suggest that some malignant breast cancers and their constitutive carcinoma cells express abundant levels of basic fibroblast growth factor mRNA. The resultant production of basic fibroblast growth factor by breast cancer cells within some tumours may contribute to their development. IMAGES:
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spelling pubmed-19688312009-09-10 Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease. Anandappa, S. Y. Winstanley, J. H. Leinster, S. Green, B. Rudland, P. S. Barraclough, R. Br J Cancer Research Article The messenger RNAs for the angiogenic acidic and basic fibroblast growth factors are expressed at a significantly higher level in samples of human benign neoplastic and hyperplastic tissue than in samples from breast cancers. However, approximately one in four malignant breast cancer samples contain basic fibroblast growth factor mRNA at the same level as in the benign lesions when basic fibroblast growth factor mRNA levels are corrected with respect to levels of expression of glyceraldehyde-3-phosphate dehydrogenase mRNA. A similar proportion of human malignant breast cancer cell lines express a high level of basic fibroblast growth factor mRNA. The results suggest that some malignant breast cancers and their constitutive carcinoma cells express abundant levels of basic fibroblast growth factor mRNA. The resultant production of basic fibroblast growth factor by breast cancer cells within some tumours may contribute to their development. IMAGES: Nature Publishing Group 1994-04 /pmc/articles/PMC1968831/ /pubmed/7511406 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Anandappa, S. Y.
Winstanley, J. H.
Leinster, S.
Green, B.
Rudland, P. S.
Barraclough, R.
Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease.
title Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease.
title_full Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease.
title_fullStr Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease.
title_full_unstemmed Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease.
title_short Comparative expression of fibroblast growth factor mRNAs in benign and malignant breast disease.
title_sort comparative expression of fibroblast growth factor mrnas in benign and malignant breast disease.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968831/
https://www.ncbi.nlm.nih.gov/pubmed/7511406
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