Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome.

The expression of sialosyl-Tn (STn) antigen was evaluated by immunohistochemistry in primary gastric cancers. Twenty-one of 31 (68%) gastric cancers expressed STn, regardless of tumour location, stage or histological type. Eighty-one per cent of patients with STn-positive tumours died of their disea...

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Detalles Bibliográficos
Autores principales: Werther, J. L., Rivera-MacMurray, S., Bruckner, H., Tatematsu, M., Itzkowitz, S. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968851/
https://www.ncbi.nlm.nih.gov/pubmed/8123499
Descripción
Sumario:The expression of sialosyl-Tn (STn) antigen was evaluated by immunohistochemistry in primary gastric cancers. Twenty-one of 31 (68%) gastric cancers expressed STn, regardless of tumour location, stage or histological type. Eighty-one per cent of patients with STn-positive tumours died of their disease or had recurrent cancer, compared with 20% of patients with STn-negative tumours (P < 0.002). STn may be a useful prognostic marker in patients with gastric cancer. IMAGES:

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