Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome.

The expression of sialosyl-Tn (STn) antigen was evaluated by immunohistochemistry in primary gastric cancers. Twenty-one of 31 (68%) gastric cancers expressed STn, regardless of tumour location, stage or histological type. Eighty-one per cent of patients with STn-positive tumours died of their disea...

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Autores principales: Werther, J. L., Rivera-MacMurray, S., Bruckner, H., Tatematsu, M., Itzkowitz, S. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968851/
https://www.ncbi.nlm.nih.gov/pubmed/8123499
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author Werther, J. L.
Rivera-MacMurray, S.
Bruckner, H.
Tatematsu, M.
Itzkowitz, S. H.
author_facet Werther, J. L.
Rivera-MacMurray, S.
Bruckner, H.
Tatematsu, M.
Itzkowitz, S. H.
author_sort Werther, J. L.
collection PubMed
description The expression of sialosyl-Tn (STn) antigen was evaluated by immunohistochemistry in primary gastric cancers. Twenty-one of 31 (68%) gastric cancers expressed STn, regardless of tumour location, stage or histological type. Eighty-one per cent of patients with STn-positive tumours died of their disease or had recurrent cancer, compared with 20% of patients with STn-negative tumours (P < 0.002). STn may be a useful prognostic marker in patients with gastric cancer. IMAGES:
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spelling pubmed-19688512009-09-10 Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome. Werther, J. L. Rivera-MacMurray, S. Bruckner, H. Tatematsu, M. Itzkowitz, S. H. Br J Cancer Research Article The expression of sialosyl-Tn (STn) antigen was evaluated by immunohistochemistry in primary gastric cancers. Twenty-one of 31 (68%) gastric cancers expressed STn, regardless of tumour location, stage or histological type. Eighty-one per cent of patients with STn-positive tumours died of their disease or had recurrent cancer, compared with 20% of patients with STn-negative tumours (P < 0.002). STn may be a useful prognostic marker in patients with gastric cancer. IMAGES: Nature Publishing Group 1994-03 /pmc/articles/PMC1968851/ /pubmed/8123499 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Werther, J. L.
Rivera-MacMurray, S.
Bruckner, H.
Tatematsu, M.
Itzkowitz, S. H.
Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome.
title Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome.
title_full Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome.
title_fullStr Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome.
title_full_unstemmed Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome.
title_short Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome.
title_sort mucin-associated sialosyl-tn antigen expression in gastric cancer correlates with an adverse outcome.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968851/
https://www.ncbi.nlm.nih.gov/pubmed/8123499
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