Inactivation of O6-alkylguanine-DNA alkyltransferase in human peripheral blood mononuclear cells by temozolomide.

O6-alkylguanine-DNA-alkyltransferase (ATase) activity was measured in extracts of peripheral blood mononuclear cells (PMCs) taken from eight patients at various times during 5 days of oral treatment with temozolomide (150 mg m-2, days 1-5). Pretreatment ATase levels ranged from approximately 70 to 6...

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Detalles Bibliográficos
Autores principales: Lee, S. M., Thatcher, N., Crowther, D., Margison, G. P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968858/
https://www.ncbi.nlm.nih.gov/pubmed/8123472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1968858/
https://www.ncbi.nlm.nih.gov/pubmed/8123472

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